Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | KCNQ4 | P56696 | 3/20 | 0.34 |
| ▸ | KCNQ5 | Q9NR82 | 3/20 | 0.34 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2900197 | 0.89 | KDM1A (0.42) | KDM1AHDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL2897902 | 0.78 | HDAC3 (0.46) | KDM1AHDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL25047628 | 0.77 | SSTR4 (0.42) | KDM1AHDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL2898059 | 0.75 | RIPK1 (0.40) | KDM1AHDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL2892096 | 0.74 | HDAC3 (0.45) | KDM1AHDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL19382135 | 0.71 | HDAC6 (0.33) | HDAC6HDAC1HDAC2CTSLCTSB | |
| SCHEMBL3913733 | 0.70 | HDAC6 (0.33) | HDAC6HDAC1HDAC2 | |
| SCHEMBL15670499 | 0.70 | KDM1A (0.35) | KDM1AHDAC8HDAC6KCNQ4KCNQ5 | |
| SCHEMBL25047640 | 0.69 | TAAR1 (0.40) | KDM1AHDAC8HDAC6RIPK1KCNQ4 | |
| SCHEMBL4691728 | 0.69 | HDAC3 (0.39) | KDM1AHDAC8HDAC6HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820680-B2 | HIV integrase inhibitors | MERCK & CO., INC. (US) | 2010-10-26 | — | — | US | disclosed |
| US-20080009490-A1 | Hiv Integrase Inhibitors | MERCK SHARP & DOHME CORP. | 2008-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009490-A1 | Hiv Integrase Inhibitors | TYMS, UNG, TYMP | KDM1A 446/4885HDAC8 1706/4885HDAC6 3355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.