Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.30 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.30 |
| ▸ | GSK3A | P49840 | 1/20 | 0.30 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.30 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15910910 | 0.81 | HASPIN (0.49) | HASPINGAAMAPTMAPK1ADORA2A | |
| SCHEMBL28920149 | 0.75 | GAA (0.34) | GAAMAPTMAPK1ADORA2AADORA2B | |
| SCHEMBL28920240 | 0.74 | RAB9A (0.44) | HASPINMAPTLMNA | |
| SCHEMBL27192250 | 0.74 | HASPIN (0.44) | HASPINMAPTTSHRLMNAMEN1 | |
| SCHEMBL31130304 | 0.72 | GRM2 (0.44) | HASPINMAPK1MEN1KMT2AKMO | |
| SCHEMBL20604815 | 0.72 | KDM4E (0.48) | HASPINGAAMAPK1TSHRMEN1 | |
| SCHEMBL15910584 | 0.71 | HASPIN (0.42) | HASPINMAPK1ADORA2AADORA2BLMNA | |
| SCHEMBL19762455 | 0.71 | HASPIN (0.36) | HASPINGAATSHRLMNAMEN1 | |
| SCHEMBL32681274 | 0.69 | HASPIN (0.39) | HASPINGSK3A | |
| SCHEMBL213305 | 0.69 | CHEK1 (0.53) | HASPINGAAMAPTMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115490709-A | KRASG12D inhibitor and application thereof in medicine | 四川海思科制药有限公司 | 2022-12-20 | — | — | CN | disclosed |