Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.31 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.31 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15910568 | 0.81 | SYK (0.38) | CHEK1AURKADAPK3CSNK1A1GSK3A | |
| SCHEMBL28920192 | 0.75 | HASPIN (0.48) | GAAMAPTCHEK1AURKADAPK3 | |
| SCHEMBL22939501 | 0.74 | KDM4E (0.42) | ADORA3ADORA2AADORA2BADORA1KDM4E | |
| SCHEMBL4083412 | 0.74 | NOS1 (0.34) | BACE1MAPK1 | |
| SCHEMBL28920185 | 0.73 | NQO2 (0.38) | MAPTCHEK1DAPK3LIMK1 | |
| SCHEMBL19762454 | 0.72 | PDE1B (0.36) | KDM4E | |
| SCHEMBL22939496 | 0.71 | ALDH1A1 (0.41) | GAAMAPTADORA3ADORA2AADORA2B | |
| SCHEMBL15910720 | 0.70 | SYK (0.33) | KDM4EMAPK1 | |
| SCHEMBL3353513 | 0.70 | ADORA3 (0.41) | AURKAADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL31304384 | 0.70 | ADORA3 (0.41) | AURKAADORA3ADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115490709-A | KRASG12D inhibitor and application thereof in medicine | 四川海思科制药有限公司 | 2022-12-20 | — | — | CN | disclosed |