Sugi Predict

Sugi Predict / Compounds / SCHEMBL2892227

SCHEMBL2892227

SCHEMBL2892227

Cc1cc(Cc2nnc(C(F)(F)F)o2)ccc1N

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SKP2 Q13309 1/20 0.39
▸ GRIN1 Q05586 2/20 0.36
▸ GRIN2B Q13224 2/20 0.36
▸ MAPT P10636 3/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ TDP1 Q9NUW8 2/20 0.34
▸ RAB9A P51151 6/20 0.34
▸ SMN1; SMN2 Q16637 5/20 0.34
▸ NPC1 O15118 5/20 0.34
▸ HPGD P15428 3/20 0.34
▸ POLB P06746 3/20 0.34
▸ S100B P04271 1/20 0.33
▸ TSHR P16473 2/20 0.33
▸ TP53 P04637 2/20 0.33
▸ LMNA P02545 1/20 0.33
▸ ALOX12 P18054 1/20 0.33
▸ KDM4E B2RXH2 1/20 0.33
▸ RAD52 P43351 1/20 0.33
▸ ALDH1A1 P00352 2/20 0.33
▸ CYP3A4 P08684 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1847192 0.80 HPGD (0.42) MAPTKMT2ATDP1RAB9ASMN1; SMN2
SCHEMBL25913320 0.76 NPSR1 (0.39) GRIN1GRIN2BMAPTKMT2ATDP1
SCHEMBL2891668 0.72 HDAC6 (0.51) MAPTKMT2ATDP1RAB9ASMN1; SMN2
SCHEMBL27912332 0.71 SKP2 (0.46) SKP2MAPTKMT2ATDP1RAB9A
SCHEMBL25516060 0.71 SKP2 (0.46) SKP2MAPTKMT2ATDP1RAB9A
SCHEMBL237201 0.71 SKP2 (0.61) SKP2MAPTKMT2ATDP1RAB9A
SCHEMBL31079561 0.71 SKP2 (0.61) SKP2MAPTKMT2ATDP1RAB9A
SCHEMBL550610 0.70 SKP2 (0.45) SKP2MAPTKMT2ATDP1RAB9A
SCHEMBL1826287 0.70 SKP2 (0.41) SKP2MAPTKMT2ATDP1RAB9A
SCHEMBL26485335 0.69 HDAC6 (0.57) MAPTKMT2ATDP1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100130743-A1 HETEROCYCLE-SUBSTITUTED, N-PHENYL-PHTHALAMIDE DERIVATIVES, RELATED COMPOUNDS AND THEIR USE AS INSECTICIDES BAYER CROPSCIENCE AG (DE) 2010-05-27 — — US disclosed
US-7674807-B2 Heterocycle-substituted n-phenyl-phthalamide derivatives, related compounds and their use as insecticides BAYER CROPSCIENCE AG (DE) 2010-03-09 — — US disclosed
US-20070299085-A1 N1-((Pyrazol-1-Ymethyl)-2-Methylphenyl)-Phatalamide Derivatives And Related Compounds Insecticides BAYER CROPSCIENCE AG (DE) 2007-12-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100130743-A1 HETEROCYCLE-SUBSTITUTED, N-PHENYL-PHTHALAMIDE DERIVATIVES, RELATED COMPOUNDS AND THEIR USE AS INSECTICIDES DDT, SQOR, CYP2S1 SKP2 1205/4885GRIN1 2167/4885GRIN2B 2680/4885
US-20070299085-A1 N1-((Pyrazol-1-Ymethyl)-2-Methylphenyl)-Phatalamide Derivatives And Related Compounds Insecticides CHRM1, KCNH1, DDT SKP2 1596/4885GRIN1 1976/4885GRIN2B 3326/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.