Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | NISCH | Q9Y2I1 | 8/20 | 0.40 |
| ▸ | PTAFR | P25105 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30089305 | 1.00 | CHRM1 (0.46) | CHRM1NISCHPTAFRADRA2AADRA2B | |
| SCHEMBL28923382 | 0.84 | GABRA1 (0.46) | CHRM1NISCHADRA1AGABRA1GABRA5 | |
| SCHEMBL28989142 | 0.77 | CHRM1 (0.45) | CHRM1PTAFRGABRA1GABRA5GABRA3 | |
| SCHEMBL23881527 | 0.76 | CHRM1 (0.77) | CHRM1PTAFRGABRA1GABRA5GABRA3 | |
| SCHEMBL23881586 | 0.76 | GABRA1 (0.56) | CHRM1ADRA1AGABRA1GABRA5GABRA3 | |
| SCHEMBL30202119 | 0.76 | CHRM1 (0.53) | CHRM1PTAFRGABRA1GABRA5GABRA3 | |
| SCHEMBL28989161 | 0.75 | NISCH (0.36) | NISCHADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL30241877 | 0.75 | NISCH (0.36) | NISCHADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL11479334 | 0.72 | NISCH (0.53) | CHRM1NISCHADRA2AADRA2BADRA2C | |
| SCHEMBL30241881 | 0.71 | NISCH (0.38) | NISCHADRA2AADRA2BADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115667262-A | Benzodiazepine derivatives as GABAA γ 1PAM | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | disclosed |
| CN-115380034-A | Benzodiazepine derivatives as GABA a γ 1 PAM | 豪夫迈·罗氏有限公司 | 2022-11-22 | — | — | CN | disclosed |