Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.45 |
| ▸ | PTAFR | P25105 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.30 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.30 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.30 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30089305 | 0.77 | CHRM1 (0.46) | CHRM1PTAFRGABRA1GABRA5GABRA3 | |
| SCHEMBL28923505 | 0.77 | CHRM1 (0.46) | CHRM1PTAFRGABRA1GABRA5GABRA3 | |
| SCHEMBL28989139 | 0.77 | NOS3 (0.32) | NOS3NOS1NOS2 | |
| SCHEMBL23881586 | 0.75 | GABRA1 (0.56) | CHRM1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL23881527 | 0.75 | CHRM1 (0.77) | CHRM1PTAFRGABRA1GABRA5GABRA3 | |
| SCHEMBL28989556 | 0.74 | CHRM1 (0.37) | CHRM1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL28989133 | 0.74 | NOS1 (0.33) | NOS3NOS1NOS2OPRK1 | |
| SCHEMBL30202119 | 0.73 | CHRM1 (0.53) | CHRM1PTAFRGABRA1GABRA5GABRA3 | |
| SCHEMBL28989132 | 0.70 | TRPA1 (0.32) | NOS3NOS1NOS2 | |
| SCHEMBL27301841 | 0.70 | CHRM1 (0.59) | CHRM1PTAFRGABRA1GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115667262-A | Benzodiazepine derivatives as GABAA γ 1PAM | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | disclosed |