Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 3/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28931885 | 0.86 | MAPK10 (0.50) | MAPK10USP2CYP11B1CYP11B2MEN1 | |
| SCHEMBL2886988 | 0.85 | NOTUM (0.51) | MEN1KMT2AALDH1A1KDM4EMAPK8 | |
| SCHEMBL25395065 | 0.75 | USP2 (0.51) | MAPK10USP2CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL28700028 | 0.75 | USP2 (0.51) | MAPK10USP2HSP90AA1HSP90B1RAB9A | |
| SCHEMBL28673167 | 0.73 | USP2 (0.55) | MAPK10USP2CYP11B1CYP11B2MEN1 | |
| SCHEMBL25281442 | 0.73 | USP2 (0.46) | MAPK10USP2CYP11B1CYP11B2MEN1 | |
| SCHEMBL28683880 | 0.72 | CYP11B1 (0.70) | MAPK10USP2CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL30444258 | 0.72 | HDAC8 (0.58) | MAPK10USP2ALDH1A1KDM4EHDAC3 | |
| SCHEMBL19900742 | 0.71 | ALDH1A1 (0.34) | KMT2AALDH1A1KDM4EMAPK8GAA | |
| SCHEMBL21839856 | 0.70 | MAPK10 (0.63) | MAPK10USP2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3930849-B1 | THIAZOLE DERIVATIVES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2025-02-19 | — | — | EP | disclosed |
| CN-113993587-A | Thiazole derivatives as protein secretion inhibitors | 科智生命科学公司 | 2022-01-28 | — | — | CN | disclosed |