Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 12/20 | 0.61 |
| ▸ | HSP90AA1 | P07900 | 11/20 | 0.61 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.50 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29366455 | 0.89 | HSP90AB1 (0.71) | HSP90AB1HSP90AA1ADORA2AHDAC6HDAC1 | |
| SCHEMBL3389606 | 0.89 | HSP90AB1 (0.71) | HSP90AB1HSP90AA1ADORA2AHDAC6HDAC1 | |
| SCHEMBL5161254 | 0.88 | CCNE2 (0.52) | HSP90AB1HSP90AA1ADORA2APOLB | |
| SCHEMBL5160796 | 0.83 | PDE8A (0.59) | HSP90AB1HSP90AA1ADORA2APOLB | |
| SCHEMBL3395507 | 0.78 | HSP90AB1 (0.74) | HSP90AB1HSP90AA1ADORA2AHDAC6HDAC1 | |
| SCHEMBL3394076 | 0.77 | HSP90AB1 (0.68) | HSP90AB1HSP90AA1ADORA2AHDAC6HDAC1 | |
| SCHEMBL3821565 | 0.76 | YTHDC1 (0.57) | HSP90AB1HSP90AA1ADORA2AHDAC6HDAC1 | |
| SCHEMBL3393681 | 0.76 | HSP90AB1 (1.00) | HSP90AB1HSP90AA1ADORA2AHDAC6HSP90B1 | |
| SCHEMBL3392226 | 0.75 | HSP90AB1 (0.77) | HSP90AB1HSP90AA1HDAC6HDAC1HDAC4 | |
| SCHEMBL5471657 | 0.75 | HSP90AA1 (0.54) | HSP90AB1HSP90AA1ADORA2AHDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113993870-B | Imidazo pyrimidine compound containing fused ring group, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2023-06-13 | — | — | CN | disclosed |
| CN-113993870-A | Imidazo pyrimidine compound containing polycyclic group, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2022-01-28 | — | — | CN | disclosed |