Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.64 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | NAMPT | P43490 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28691401 | 0.99 | EPHX2 (0.62) | EPHX2NPC1RAB9AKMT2ANAMPT | |
| SCHEMBL28691382 | 0.94 | EPHX2 (0.54) | EPHX2NPC1RAB9AKMT2ANAMPT | |
| SCHEMBL28700605 | 0.82 | HPGD (0.60) | NPC1KMT2AHPGDSMN1; SMN2TSHR | |
| SCHEMBL28690649 | 0.82 | HPGD (0.60) | NPC1KMT2AHPGDSMN1; SMN2TSHR | |
| SCHEMBL28685818 | 0.81 | HPGD (0.57) | NPC1RAB9AKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL3822162 | 0.79 | EPHX2 (1.00) | EPHX2NPC1RAB9AKMT2ANAMPT | |
| SCHEMBL28698349 | 0.79 | NPC1 (0.61) | NPC1RAB9AKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL28697081 | 0.78 | HPGD (0.62) | KMT2AHPGDSMN1; SMN2MEN1KDM4E | |
| SCHEMBL28704844 | 0.78 | HPGD (0.54) | NPC1RAB9AKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL4866294 | 0.78 | EPHX2 (0.97) | EPHX2NPC1RAB9AKMT2ANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114057630-B | Pirfenidone derivative and synthetic method and application thereof | 郑州大学 | 2023-06-02 | — | — | CN | claimed |
| CN-114057630-A | Pirfenidone derivative and synthetic method and application thereof | 郑州大学 | 2022-02-18 | — | — | CN | claimed |
| CN-114057630-B | Pirfenidone derivative and synthetic method and application thereof | 郑州大学 | 2023-06-02 | — | — | CN | disclosed |
| CN-114057630-A | Pirfenidone derivative and synthetic method and application thereof | 郑州大学 | 2022-02-18 | — | — | CN | disclosed |