SCHEMBL2893483

SCHEMBL2893483

COC(=O)[C@@H](SC(=S)c1ccccc1)c1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.51
PTGS1 P23219 1/20 0.47
PTGS2 P35354 1/20 0.47
TSHR P16473 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
LMNA P02545 3/20 0.41
ALDH1A1 P00352 3/20 0.41
GLA P06280 1/20 0.41
MEN1 O00255 2/20 0.40
GAA P10253 1/20 0.39
TDP1 Q9NUW8 2/20 0.39
MAPT P10636 1/20 0.39
CYP3A4 P08684 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL237873 1.00 KMT2A (0.51) KMT2APTGS1PTGS2TSHRSMN1; SMN2
SCHEMBL13305895 0.91 KMT2A (0.46) KMT2APTGS1PTGS2SMN1; SMN2NPSR1
SCHEMBL13305881 0.91 KMT2A (0.46) KMT2APTGS1PTGS2TSHRSMN1; SMN2
SCHEMBL16841424 0.85 KMT2A (0.53) KMT2APTGS1PTGS2TSHRSMN1; SMN2
SCHEMBL12892652 0.84 KDM4E (0.50) KMT2ATSHRSMN1; SMN2ALDH1A1MEN1
SCHEMBL16093068 0.83 KMT2A (0.50) KMT2APTGS1PTGS2TSHRSMN1; SMN2
SCHEMBL16128973 0.81 TDP1 (0.44) PTGS1PTGS2TSHRSMN1; SMN2LMNA
SCHEMBL12423871 0.80 KMT2A (0.47) KMT2APTGS1PTGS2TSHRSMN1; SMN2
Propane SCHEMBL3346178 0.80 KMT2A (0.47) KMT2APTGS1PTGS2TSHRSMN1; SMN2
SCHEMBL16866714 0.80 CHRM1 (0.40) SMN1; SMN2NPSR1LMNAALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230220442-A1 Random Heteropolymers Preserve Protein Function in Foreign Environments THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-07-13 US disclosed
US-11629372-B2 Random heteropolymers preserve protein function in foreign environments THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-04-18 US disclosed
EP-3359580-B1 POLYMER HAVING ANTIMICROBIAL AND/OR ANTIFOULING PROPERTIES UNIV FREIBURG ALBERT LUDWIGS (DE) 2022-03-30 EP disclosed
US-10889726-B2 Polymer having antimicrobial and/or antifouling properties ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG (DE) 2021-01-12 US disclosed
US-20200318154-A1 Random Heteropolymers Preserve Protein Function in Foreign Environments THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2020-10-08 US disclosed
US-20180327607-A1 POLYMER HAVING ANTIMICROBIAL AND/OR ANTIFOULING PROPERTIES ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG (DE) 2018-11-15 US disclosed
US-8518497-B2 Methods for the preparation of coil-comb block copolymers and their nanostructures KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2013-08-27 US disclosed
US-20100285276-A1 Methods for the preparation of coil-comb block copolymers and their nanostructures KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2010-11-11 US disclosed
US-20100160574-A1 Polymerisation Using Chain Transfer Agents THE UNIVERSITY OF LEEDS (GB) 2010-06-24 US disclosed
US-20090215965-A1 POLYMERISATION USING CHAIN TRANSFER AGENTS THE UNIVERSITY OF LEEDS (GB) 2009-08-27 US disclosed
US-20070299221-A1 Polymerisation Using Chain Transfer Agents UNIVERSITY OF LEEDS, THE (GB) 2007-12-27 US disclosed
EP-1697424-A1 POLYMERISATION USING CHAIN TRANSFER AGENTS THE UNIVERSITY OF LEEDS (GB) 2006-09-06 EP disclosed
WO-2005061555-A1 POLYMERISATION USING CHAIN TRANSFER AGENTS THE UNIVERSITY OF LEEDS (GB) 2005-07-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100160574-A1 Polymerisation Using Chain Transfer Agents TRRAP, TRMT1, IPO11 KMT2A 1898/4885PTGS1 1017/4885PTGS2 1223/4885
US-20090215965-A1 POLYMERISATION USING CHAIN TRANSFER AGENTS TRRAP, TRMT1, IPO11 KMT2A 1898/4885PTGS1 1017/4885PTGS2 1223/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.