Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 4/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.44 |
| ▸ | RPLP1 | P05386 | 5/20 | 0.36 |
| ▸ | RPLP0 | P05388 | 5/20 | 0.36 |
| ▸ | RPS17 | P08708 | 5/20 | 0.36 |
| ▸ | RPSA | P08865 | 5/20 | 0.36 |
| ▸ | RPS2 | P15880 | 5/20 | 0.36 |
| ▸ | RPL35A | P18077 | 5/20 | 0.36 |
| ▸ | RPL7 | P18124 | 5/20 | 0.36 |
| ▸ | RPL17 | P18621 | 5/20 | 0.36 |
| ▸ | RPS4Y1 | P22090 | 5/20 | 0.36 |
| ▸ | RPS3 | P23396 | 5/20 | 0.36 |
| ▸ | RPS12 | P25398 | 5/20 | 0.36 |
| ▸ | RPL13 | P26373 | 5/20 | 0.36 |
| ▸ | RPL10 | P27635 | 5/20 | 0.36 |
| ▸ | RPL12 | P30050 | 5/20 | 0.36 |
| ▸ | RPL9; RPL9P7; RPL9P8; RPL9P9 | P32969 | 5/20 | 0.36 |
| ▸ | RPL22 | P35268 | 5/20 | 0.36 |
| ▸ | RPL4 | P36578 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30108895 | 1.00 | CHEK2 (0.45) | CHEK2KCNH2CHEK1RPLP1RPLP0 | |
| SCHEMBL28934843 | 1.00 | CHEK2 (0.45) | CHEK2KCNH2CHEK1RPLP1RPLP0 | |
| SCHEMBL24840762 | 0.81 | NLRP3 (0.51) | NLRP3IL1B | |
| SCHEMBL30108706 | 0.81 | NLRP3 (0.51) | NLRP3IL1B | |
| SCHEMBL24840029 | 0.81 | NLRP3 (0.51) | NLRP3IL1B | |
| SCHEMBL28934321 | 0.79 | NLRP3 (0.41) | NLRP3IL1B | |
| SCHEMBL28934320 | 0.79 | NLRP3 (0.41) | NLRP3IL1B | |
| SCHEMBL28934254 | 0.78 | CHEK1 (0.42) | CHEK2KCNH2CHEK1NLRP3ALOX5AP | |
| SCHEMBL28934253 | 0.78 | CHEK1 (0.42) | CHEK2KCNH2CHEK1NLRP3ALOX5AP | |
| SCHEMBL30108814 | 0.78 | CHEK1 (0.42) | CHEK2KCNH2CHEK1NLRP3ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115433163-A | NLRP3 inflammasome inhibitor and application thereof | 药捷安康(南京)科技股份有限公司 | 2022-12-06 | — | — | CN | disclosed |