Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16877209 | 0.81 | PDK1 (0.42) | DRD3PDK1KDM1ADRD1 | |
| SCHEMBL9067866 | 0.80 | DRD3 (0.37) | DRD3PDK1KDM1ADRD1 | |
| SCHEMBL29946367 | 0.79 | PDK1 (0.41) | DRD3PDK1KDM1ADRD1 | |
| SCHEMBL28976304 | 0.79 | PDK1 (0.41) | DRD3PDK1KDM1ADRD1 | |
| Bromide SCHEMBL14811352 | 0.76 | PDK1 (0.44) | DRD3PDK1KDM1ADRD1SIGMAR1 | |
| SCHEMBL774483 | 0.76 | — | — | |
| SCHEMBL16767725 | 0.74 | DRD3 (0.43) | DRD3SIGMAR1 | |
| SCHEMBL1072148 | 0.74 | SIGMAR1 (0.44) | PDK1KDM4ELMNASIGMAR1 | |
| SCHEMBL13415808 | 0.74 | — | — | |
| SCHEMBL10815846 | 0.74 | SIGMAR1 (0.44) | PDK1KDM4ELMNASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114507126-B | Preparation process and application of 6-gingerol | 中国科学院地球化学研究所 | 2023-03-17 | — | — | CN | disclosed |
| CN-114507126-A | Preparation process and application of 6-gingerol | 中国科学院地球化学研究所 | 2022-05-17 | — | — | CN | disclosed |