Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ropinirole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 15/20 | 0.95 |
| ▸ | DRD4 known ✓ | P21917 | 2/20 | 0.95 |
| ▸ | DRD3 known ✓ | P35462 | 2/20 | 0.95 |
| ▸ | DRD1 | P21728 | 2/20 | 0.95 |
| ▸ | DRD5 | P21918 | 2/20 | 0.95 |
| ▸ | HTR1A | P08908 | 2/20 | 0.95 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.95 |
| ▸ | LMNA | P02545 | 1/20 | 0.95 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.95 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.95 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.95 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.95 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.95 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.95 |
| ▸ | HTR2A | P28223 | 1/20 | 0.95 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.95 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.95 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.95 |
| ▸ | HRH1 | P35367 | 1/20 | 0.95 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.95 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ropinirole SCHEMBL29374522 | 0.97 | DRD2 (1.00) | DRD2DRD1DRD4DRD5DRD3 | |
| Ropinirole SCHEMBL35212 | 0.97 | DRD2 (1.00) | DRD2DRD1DRD4DRD5DRD3 | |
| Ropinirole SCHEMBL4623647 | 0.96 | APEX1 (1.00) | DRD2DRD1DRD4DRD5DRD3 | |
| Ropinirole SCHEMBL1787068 | 0.96 | APEX1 (1.00) | DRD2DRD1DRD4DRD5DRD3 | |
| Ropinirole SCHEMBL16044076 | 0.96 | DRD2 (0.97) | DRD2DRD1DRD4DRD5DRD3 | |
| Ropinirole SCHEMBL29366889 | 0.96 | APEX1 (1.00) | DRD2DRD1DRD4DRD5DRD3 | |
| Ropinirole SCHEMBL40760 | 0.96 | APEX1 (1.00) | DRD2DRD1DRD4DRD5DRD3 | |
| Ropinirole SCHEMBL29278850 | 0.96 | DRD2 (0.97) | DRD2DRD1DRD4DRD5DRD3 | |
| Ropinirole SCHEMBL678982 | 0.95 | DRD2 (0.95) | DRD2DRD1DRD4DRD5DRD3 | |
| Ropinirole SCHEMBL28866728 | 0.92 | APEX1 (0.93) | DRD2DRD1DRD4DRD5DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115466209-A | Synthesis method of ropinirole cyclopentanoindolone impurity | 南通大学 | 2022-12-13 | — | — | CN | claimed |
| CN-115466209-A | Synthesis method of ropinirole cyclopentanoindolone impurity | 南通大学 | 2022-12-13 | — | — | CN | disclosed |
| CN-115466209-A | Synthesis method of ropinirole cyclopentanoindolone impurity | 南通大学 | 2022-12-13 | — | — | CN | disclosed |