Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ropinirole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 15/20 | 0.97 |
| ▸ | DRD4 known ✓ | P21917 | 2/20 | 0.97 |
| ▸ | DRD3 known ✓ | P35462 | 2/20 | 0.97 |
| ▸ | APEX1 | P27695 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | DRD1 | P21728 | 2/20 | 0.97 |
| ▸ | DRD5 | P21918 | 2/20 | 0.97 |
| ▸ | HTR1A | P08908 | 2/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.97 |
| ▸ | LMNA | P02545 | 1/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.97 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.97 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.97 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.97 |
| ▸ | HTR2A | P28223 | 1/20 | 0.97 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ropinirole SCHEMBL29366889 | 1.00 | APEX1 (1.00) | APEX1BLMDRD2DRD1DRD4 | |
| Ropinirole SCHEMBL4623647 | 1.00 | APEX1 (1.00) | APEX1BLMDRD2DRD1DRD4 | |
| Ropinirole SCHEMBL1787068 | 1.00 | APEX1 (1.00) | APEX1BLMDRD2DRD1DRD4 | |
| Ropinirole SCHEMBL35212 | 0.99 | DRD2 (1.00) | APEX1BLMDRD2DRD1DRD4 | |
| Ropinirole SCHEMBL29374522 | 0.99 | DRD2 (1.00) | APEX1BLMDRD2DRD1DRD4 | |
| Ropinirole SCHEMBL29278850 | 0.97 | DRD2 (0.97) | APEX1BLMDRD2DRD1DRD4 | |
| Ropinirole SCHEMBL16044076 | 0.97 | DRD2 (0.97) | APEX1BLMDRD2DRD1DRD4 | |
| Ropinirole SCHEMBL28866728 | 0.96 | APEX1 (0.93) | APEX1BLMDRD2DRD1DRD4 | |
| Ropinirole SCHEMBL678982 | 0.96 | DRD2 (0.95) | APEX1BLMDRD2DRD1DRD4 | |
| Ropinirole SCHEMBL28937023 | 0.96 | DRD2 (0.95) | APEX1BLMDRD2DRD1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5814 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122028915-A | Frontotemporal lobar degenerative disease therapeutic agent and therapeutic composition | 凯制药股份有限公司 | 2026-05-12 | — | — | CN | claimed |
| US-20260000910-A1 | METHOD FOR TREATING PARKINSON'S DISEASE THROUGH PHOTOSTIMULATION, AND DEVICE USED IN SAID METHOD | TSUBOTA LAB INC (JP) | 2026-01-01 | — | — | US | claimed |
| US-20250382291-A1 | SUBSTITUTED PYRROLO[2,3-b]PYRIDINES FOR SUPPRESSING TOXIC ENDOPLASMIC RETICULUM STRESS | UNIV COLUMBIA (US) | 2025-12-18 | — | — | US | claimed |
| US-20250329454-A1 | DIAGNOSTIC INDICES FOR NEURODEGENERATIVE CONDITIONS | CHASE THERAPEUTICS CORP (US) | 2025-10-23 | — | — | US | claimed |
| CN-120155244-A | Preparation method of dearsenifying agent NP201 for alkaline leaching system | 云南瀚驰新材料股份有限公司 | 2025-06-17 | — | — | CN | claimed |
| CN-120068081-A | Intelligent contract vulnerability detection method and system based on multi-mode data | 天津理工大学 | 2025-05-30 | — | — | CN | claimed |
| WO-2025095099-A1 | THERAPEUTIC AGENT FOR FRONTOTEMPORAL LOBAR DEGENERATION AND THERAPEUTIC COMPOSITION | 株式会社ケイファーマ | 2025-05-08 | — | — | WO | claimed |
| CN-119886643-A | Multi-order scheduling method and device for spinning enterprises based on thought tree structure | 联通(福建)产业互联网有限公司 | 2025-04-25 | — | — | CN | claimed |
| EP-4540083-A1 | METHOD AND SYSTEM FOR CONTROLLING A HYBRID MOTOR VEHICLE DURING DECELERATIONS | Horse Powertrain Solutions, S.L.U. (ES) | 2025-04-23 | — | — | EP | claimed |
| EP-4537896-A1 | METHOD FOR TREATING PARKINSON'S DISEASE THROUGH PHOTOSTIMULATION, AND DEVICE USED IN SAID METHOD | Juntendo Educational Foundation (JP) | 2025-04-16 | — | — | EP | claimed |
| WO-1994015918-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED INDOLONE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1994-07-21 | — | — | WO | claimed |
| EP-0526529-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF SUBSTITUTED INDOLONE DERIVATIVES. | SMITH KLINE FRENCH LAB (GB) | 1993-02-10 | — | — | EP | claimed |
| EP-0299602-B1 | USE OF INDOLONE DERIVATIVES FOR THE PREPARATION OF MEDICAMENTS FOR THE TREATMENT OF PARKINSONS DISEASE | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-12-23 | — | — | EP | claimed |
| WO-1991016306-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF SUBSTITUTED INDOLONE DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-10-31 | — | — | WO | claimed |
| US-4912126-A | Containing amine substituted in position 4 | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-03-27 | — | — | US | claimed |
| US-4824860-A | Treatment of Parkinsons disease | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-04-25 | — | — | US | claimed |
| EP-0113964-B1 | 4-AMINOALKYL-2(3H)-INDOLONES | SMITHKLINE BECKMAN CORPORATION (US) | 1986-10-22 | — | — | EP | claimed |
| US-4588740-A | Pharmaceutical methods using 4-aminoalkyl-2(3H)-indolones | SMITHKLINE BECKMAN CORPORATION (US) | 1986-05-13 | — | — | US | claimed |
| EP-0113964-A1 | 4-Aminoalkyl-2(3H)-indolones | SMITHKLINE BECKMAN CORPORATION (US) | 1984-07-25 | — | — | EP | claimed |
| US-4452808-A | HYPOTENSIVE AGENTS | SMITHKLINE BECKMAN CORPORATION (US) | 1984-06-05 | — | — | US | claimed |