Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 2/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | CBLB | Q13191 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29626649 | 1.00 | RXFP1 (0.45) | RXFP1ACSS2SYKAKR1C3BRD4 | |
| SCHEMBL21200369 | 0.88 | AKR1C3 (0.40) | ACSS2AKR1C3CBLBTSHRSMN1; SMN2 | |
| SCHEMBL22944950 | 0.83 | CBLB (0.52) | RXFP1ACSS2SYKAKR1C3BRD4 | |
| SCHEMBL29640156 | 0.83 | CBLB (0.52) | RXFP1ACSS2SYKAKR1C3BRD4 | |
| SCHEMBL24660946 | 0.82 | RXFP1 (0.46) | RXFP1ACSS2SYKCYP17A1AURKB | |
| SCHEMBL29866989 | 0.78 | HCRTR1 (0.45) | RXFP1ACSS2SYKBRD4CYP17A1 | |
| SCHEMBL28741805 | 0.76 | MEN1 (0.40) | HCRTR1HCRTR2CBLB | |
| SCHEMBL1013325 | 0.74 | RXFP1 (0.73) | RXFP1L3MBTL1SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL30042580 | 0.74 | RXFP1 (0.73) | RXFP1L3MBTL1SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL22944961 | 0.73 | CBLB (0.62) | RXFP1ACSS2AKR1C3RORCCBLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114450271-B | Ureas, amino and substituted heteroaryl compounds for Cbl-b inhibition | 纽力克斯治疗公司 | 2024-09-20 | — | — | CN | disclosed |
| CN-114450271-A | Ureas, amino and substituted heteroaryl compounds for Cbl-b inhibition | 纽力克斯治疗公司 | 2022-05-06 | — | — | CN | disclosed |