Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20203398 | 0.82 | PDCD1 (0.36) | KMT2AMAPTSMN1; SMN2HPGDKDM4E | |
| SCHEMBL21403201 | 0.82 | PDCD1 (0.36) | KMT2AMAPTSMN1; SMN2HPGDKDM4E | |
| SCHEMBL28755052 | 0.80 | TP53 (0.47) | KMT2AMAPTSMN1; SMN2HPGDKDM4E | |
| SCHEMBL23733434 | 0.69 | NPC1 (0.33) | KMT2ASMN1; SMN2LMNAALDH1A1NPC1 | |
| SCHEMBL20037707 | 0.69 | NPSR1 (0.35) | KMT2AMAPTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL23733435 | 0.68 | MEN1 (0.35) | KMT2ALMNAALDH1A1MAPK1NPC1 | |
| SCHEMBL20203415 | 0.68 | LMNA (0.33) | LMNANPC1 | |
| SCHEMBL21403227 | 0.66 | AKT1 (0.34) | KMT2AMAPTSMN1; SMN2HPGDKDM4E | |
| SCHEMBL29048993 | 0.65 | KMT2A (0.41) | KMT2AMAPTSMN1; SMN2HPGDKDM4E | |
| SCHEMBL25271973 | 0.64 | SMN1; SMN2 (0.40) | KMT2AMAPTSMN1; SMN2HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110036012-B | Pyrido [3,4-d ] pyrimidine derivatives and pharmaceutically acceptable salts thereof | 帝人制药株式会社 | 2022-05-10 | — | — | CN | disclosed |