Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 7/20 | 0.42 |
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27727700 | 0.92 | SRC (0.47) | KMT2ARXFP1PDE5APDE1APDE1B | |
| SCHEMBL27707040 | 0.90 | NPC1 (0.46) | KMT2ARXFP1PDE5APDE1APDE1B | |
| SCHEMBL27727703 | 0.90 | NPC1 (0.48) | KMT2APDE5APDE1APDE1BPDE1C | |
| SCHEMBL27727902 | 0.88 | NPC1 (0.46) | KMT2ARXFP1PDE5APDE1APDE1B | |
| SCHEMBL27727655 | 0.87 | ALOX5 (0.50) | KMT2ARXFP1PDE5APDE1APDE1B | |
| SCHEMBL27727763 | 0.87 | RAB9A (0.57) | KMT2ARXFP1PDE5APDE1APDE1B | |
| SCHEMBL27706888 | 0.86 | KDM4E (0.56) | KMT2APDE5APDE1APDE1BPDE1C | |
| SCHEMBL27727782 | 0.86 | KDM4E (0.47) | KMT2APDE5APDE1APDE1BPDE1C | |
| SCHEMBL27727826 | 0.84 | PDE5A (0.45) | KMT2ARXFP1PDE5APDE1APDE1B | |
| SCHEMBL27707015 | 0.84 | PDE5A (0.47) | KMT2ARXFP1PDE5APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101208089-A | Aminothiazole derivatives as human stearoyl-CoA desaturase inhibitors | XENON PHARMACEUTICALS INC (CA) | 2008-06-25 | — | — | CN | claimed |
| CN-101208089-A | Aminothiazole derivatives as human stearoyl-CoA desaturase inhibitors | XENON PHARMACEUTICALS INC (CA) | 2008-06-25 | — | — | CN | disclosed |