Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 7/20 | 0.53 |
| ▸ | PRKDC | P78527 | 11/20 | 0.51 |
| ▸ | PDE2A | O00408 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.49 |
| ▸ | XRCC6 | P12956 | 1/20 | 0.48 |
| ▸ | XRCC5 | P13010 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27889932 | 0.87 | PRKDC (0.55) | P2RY12PRKDCPDE2APIK3CDPIK3CA | |
| SCHEMBL27873586 | 0.84 | PIK3CB (0.51) | P2RY12PRKDCPIK3CDPIK3CAPIK3CG | |
| SCHEMBL13449184 | 0.82 | PRKDC (0.58) | P2RY12PRKDCPIK3CDPIK3CAPIK3CG | |
| SCHEMBL8881978 | 0.82 | P2RY12 (0.55) | P2RY12PRKDCPIK3CDPIK3CAPIK3CG | |
| SCHEMBL1638322 | 0.80 | PRKDC (0.55) | P2RY12PRKDCPIK3CDPIK3CAPIK3CG | |
| SCHEMBL24714393 | 0.79 | PRKDC (0.59) | P2RY12PRKDCPDE2APIK3CDPIK3CA | |
| SCHEMBL1638958 | 0.79 | PIK3CA (0.53) | PRKDCPDE2APIK3CDPIK3CAPIK3CG | |
| SCHEMBL27951095 | 0.78 | P2RY12 (0.44) | P2RY12PRKDCPDE2APIK3CDPIK3CA | |
| SCHEMBL27937985 | 0.78 | P2RY12 (0.44) | P2RY12PRKDCPDE2APIK3CDPIK3CA | |
| SCHEMBL1637213 | 0.77 | PIK3CB (0.63) | PIK3CDPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103596948-B | Benzopyranone compounds as PI 3-kinase inhibitors for the treatment of cancer | ASTRAZENECA AB (SE) | 2016-04-27 | — | — | CN | disclosed |
| CN-104447657-A | CHROMENONE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | ASTRAZENECA AB | 2015-03-25 | — | — | CN | disclosed |
| CN-102712615-B | Chromenone Derivatives with Antitumor Activity | ASTRAZENECA AB | 2014-12-17 | — | — | CN | disclosed |
| CN-103596948-A | Benzopyranone compounds as PI 3-kinase inhibitors for the treatment of cancer | ASTRAZENECA AB | 2014-02-19 | — | — | CN | disclosed |
| CN-102712615-A | Chromenone Derivatives with Antitumor Activity | ASTRAZENECA AB | 2012-10-03 | — | — | CN | disclosed |