Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.44 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28947688 | 1.00 | TSHR (0.44) | TSHRLMNACYP3A4GABRA1GABRG2 | |
| SCHEMBL4318930 | 0.98 | TSHR (0.46) | TSHRLMNACYP3A4GABRA1GABRG2 | |
| SCHEMBL12520312 | 0.84 | TSHR (0.38) | TSHRLMNACYP3A4GABRA1GABRG2 | |
| SCHEMBL17159759 | 0.76 | — | — | |
| SCHEMBL16499932 | 0.75 | EPHX2 (0.32) | EPHX2 | |
| SCHEMBL1093575 | 0.73 | — | — | |
| SCHEMBL5048142 | 0.73 | LMNA (0.46) | TSHRLMNACYP3A4GABRA1GABRG2 | |
| SCHEMBL5212 | 0.73 | — | — | |
| SCHEMBL4620125 | 0.73 | TSHR (0.63) | TSHRLMNACYP3A4GABRA1GABRG2 | |
| SCHEMBL9991970 | 0.72 | TSHR (0.39) | TSHRLMNACYP3A4GABRA1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115698009-A | CD73 inhibiting 2,4-dioxopyrimidine compounds | 吉利德科学公司 | 2023-02-03 | — | — | CN | disclosed |