Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
| ▸ | HCAR1 | Q9BXC0 | 11/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31001803 | 0.81 | HCAR1 (0.36) | PLATHCAR1CRBNDDB1 | |
| SCHEMBL14269847 | 0.78 | CRBN (0.38) | HCAR1CRBNIRAK4 | |
| SCHEMBL10190930 | 0.78 | CRBN (0.34) | PLATHCAR1CRBNDDB1IRAK4 | |
| SCHEMBL406392 | 0.74 | PLAT (0.46) | PLATALDH1A1IRAK4 | |
| SCHEMBL17821034 | 0.74 | PLAT (0.46) | PLATCRBNALDH1A1SMN1; SMN2 | |
| SCHEMBL23948426 | 0.70 | TDO2 (0.40) | HCAR1NPC1ALDH1A1LMNAMAPT | |
| SCHEMBL15261212 | 0.68 | PLAT (0.53) | PLATNPC1ALDH1A1LMNAMAPT | |
| SCHEMBL23948296 | 0.68 | TDO2 (0.41) | PLATHCAR1CRBNALDH1A1MAPT | |
| SCHEMBL23947915 | 0.66 | HCAR1 (0.36) | PLATHCAR1 | |
| SCHEMBL103383 | 0.66 | PLAT (0.56) | PLATHCAR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115677705-A | AAK1 inhibitor and application thereof | 武汉人福创新药物研发中心有限公司 | 2023-02-03 | — | — | CN | disclosed |
| CN-115677729-A | AAK1 inhibitors | 武汉人福创新药物研发中心有限公司 | 2023-02-03 | — | — | CN | disclosed |