Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.43 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.43 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30152357 | 1.00 | MAPT (0.51) | MAPTALDH1A1LMNAPTPN11KCNH2 | |
| SCHEMBL16854515 | 0.81 | PTPN11 (0.51) | MAPTALDH1A1LMNAPTPN11MAP4K4 | |
| SCHEMBL5009096 | 0.81 | MAPT (0.50) | MAPTALDH1A1LMNAPTPN11KCNH2 | |
| SCHEMBL13994729 | 0.81 | ALDH1A1 (0.50) | MAPTALDH1A1LMNAPTPN11KCNH2 | |
| SCHEMBL18163291 | 0.80 | PTPN11 (0.58) | MAPTALDH1A1LMNAPTPN11KCNH2 | |
| SCHEMBL10297496 | 0.75 | GPR119 (0.55) | MAPTALDH1A1LMNAPTPN11MAP4K4 | |
| SCHEMBL902777 | 0.74 | KCNH2 (0.52) | MAPTALDH1A1LMNAPTPN11KCNH2 | |
| SCHEMBL4233300 | 0.74 | MAPT (0.53) | MAPTALDH1A1LMNAPTPN11KCNH2 | |
| SCHEMBL29546457 | 0.74 | MAP4K4 (0.59) | MAPTALDH1A1LMNAPTPN11KCNH2 | |
| SCHEMBL110185 | 0.74 | MAP4K4 (0.59) | MAPTALDH1A1LMNAPTPN11KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108250196-B | Process for the preparation of (piperazin-1-yl) -1-hydro-imidazoheteroaromatic compounds | 上海汇伦医药股份有限公司 | 2022-12-30 | — | — | CN | disclosed |