SCHEMBL28948818

SCHEMBL28948818

CC(C)(C)OC(=O)Nc1ncnc2c1ncn2Cc1c(OCCCC(NC(=O)OC(C)(C)C)C(=O)O)ccc(Cl)c1Cl

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SLC29A1 Q99808 1/20 0.35
PDE4A P27815 1/20 0.35
PDE4B Q07343 1/20 0.35
PDE4C Q08493 1/20 0.35
PDE4D Q08499 1/20 0.35
HTT P42858 2/20 0.34
P2RX3 P56373 1/20 0.34
FGFR1 P11362 3/20 0.34
FGFR4 P22455 3/20 0.34
HDAC1 Q13547 2/20 0.33
HDAC2 Q92769 1/20 0.33
ITGB3 P05106 1/20 0.33
ITGA2B P08514 1/20 0.33
EGFR P00533 1/20 0.33
P2RY2 P41231 1/20 0.32
ALDH1A1 P00352 1/20 0.32
TSHR P16473 1/20 0.32
HDAC6 Q9UBN7 1/20 0.32
CTSK P43235 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28948817 1.00 SLC29A1 (0.35) SLC29A1PDE4APDE4BPDE4CPDE4D
SCHEMBL31028256 0.93 SLC29A1 (0.35) SLC29A1PDE4APDE4BPDE4CPDE4D
SCHEMBL31028250 0.92 FGFR1 (0.34) SLC29A1PDE4APDE4BPDE4CPDE4D
SCHEMBL31028279 0.91 FGFR1 (0.33) SLC29A1PDE4APDE4BPDE4CPDE4D
SCHEMBL24075627 0.90 P2RX3 (0.36) SLC29A1PDE4APDE4BPDE4CPDE4D
SCHEMBL28821449 0.90 P2RX3 (0.36) SLC29A1PDE4APDE4BPDE4CPDE4D
SCHEMBL29727327 0.90 P2RX3 (0.36) SLC29A1PDE4APDE4BPDE4CPDE4D
SCHEMBL24075523 0.90 DOT1L (0.35) SLC29A1PDE4APDE4BPDE4CPDE4D
SCHEMBL24075550 0.90 SLC29A1 (0.35) SLC29A1PDE4APDE4BPDE4CPDE4D
SCHEMBL31028276 0.88 SLC29A1 (0.32) SLC29A1PDE4APDE4BPDE4CPDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114929705-A MLL1 inhibitor and anticancer agent 诺华公司 2022-08-19 CN disclosed