Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.47 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.47 |
| ▸ | PPARG | P37231 | 7/20 | 0.47 |
| ▸ | PPARD | Q03181 | 7/20 | 0.47 |
| ▸ | PPARA | Q07869 | 7/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TLR2 | O60603 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | FABP4 | P15090 | 2/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.47 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL29267917 | 1.00 | GPR84 (0.47) | GPR84PPARGPPARDPPARAHDAC11 | |
| Citric Acid SCHEMBL27493476 | 0.99 | AKR1B1 (0.46) | GPR84PPARGPPARDPPARAHDAC11 | |
| Citric Acid SCHEMBL27608583 | 0.94 | ALDH1A1 (0.44) | GPR84PPARGPPARDPPARAHDAC11 | |
| Citric Acid SCHEMBL29055894 | 0.94 | ALDH1A1 (0.47) | GPR84PPARGPPARDPPARAHDAC11 | |
| Citric Acid SCHEMBL27627711 | 0.88 | ALDH1A1 (0.47) | TSHRALDH1A1KMT2AALOX15MEN1 | |
| Citric Acid SCHEMBL29009071 | 0.88 | ALDH1A1 (0.50) | TSHRALDH1A1TDP1KMT2AALOX15 | |
| Octanoic Acid SCHEMBL5029655 | 0.87 | GPR84 (0.63) | GPR84PPARGPPARDPPARAHDAC11 | |
| Citric Acid SCHEMBL30466185 | 0.87 | ALDH1A1 (0.56) | TSHRALDH1A1KMT2AALOX15MEN1 | |
| Decanoic Acid SCHEMBL28992684 | 0.87 | GPR84 (0.63) | GPR84PPARGPPARDPPARAHDAC11 | |
| Hexanoate SCHEMBL23236464 | 0.85 | AKR1B1 (0.61) | GPR84PPARGPPARDPPARAHDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116655479-A | Synthetic method of novel fertilizer synergist diethylaminoethanol caprylate citrate | 河南省精细化工研究院有限公司 | 2023-08-29 | — | — | CN | claimed |
| CN-217189573-U | Caprylic acid diethylaminoethanol ester citrate production system | 河南省精细化工研究院有限公司 | 2022-08-16 | — | — | CN | claimed |
| CN-118892061-B | Production method and production equipment of SPF high-performance spray-seeding matrix | 宁国市东南木纤维科技有限公司 | 2024-12-13 | — | — | CN | disclosed |
| CN-118892061-A | Production method and production equipment of SPF high-performance spray-seeding matrix | 宁国市东南木纤维科技有限公司 | 2024-11-05 | — | — | CN | disclosed |
| CN-118063336-A | Fatty acid diethylaminoethanol ester citrate | 郑州郑氏化工产品有限公司 | 2024-05-24 | — | — | CN | disclosed |
| CN-116655479-A | Synthetic method of novel fertilizer synergist diethylaminoethanol caprylate citrate | 河南省精细化工研究院有限公司 | 2023-08-29 | — | — | CN | disclosed |
| CN-116655479-A | Synthetic method of novel fertilizer synergist diethylaminoethanol caprylate citrate | 河南省精细化工研究院有限公司 | 2023-08-29 | — | — | CN | disclosed |
| CN-116655479-A | Synthetic method of novel fertilizer synergist diethylaminoethanol caprylate citrate | 河南省精细化工研究院有限公司 | 2023-08-29 | — | — | CN | disclosed |