SCHEMBL28950804

SCHEMBL28950804

O=C(O)/C(=C\NCc1ccccc1)C(F)(F)F

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADH1B P00325 1/20 0.47
ADH1C P00326 1/20 0.47
ADH1A P07327 1/20 0.47
ADH7 P40394 1/20 0.47
CES1 P23141 3/20 0.44
HDAC3 O15379 1/20 0.42
HDAC4 P56524 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
CYP2C19 P33261 2/20 0.41
CYP2C9 P11712 1/20 0.41
ALDH1A1 P00352 5/20 0.40
MAPT P10636 2/20 0.40
LMNA P02545 1/20 0.40
NPC1 O15118 1/20 0.40
HPGD P15428 1/20 0.40
RAB9A P51151 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
CYP2D6 P10635 1/20 0.40
TSHR P16473 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28944284 0.86 ALDH1A1 (0.45) HDAC3HDAC4HDAC1HDAC6ALDH1A1
SCHEMBL30703055 0.75 ALDH1A1 (0.40) HDAC1HDAC6CYP2C19CYP2C9ALDH1A1
SCHEMBL7449222 0.74 ADH1B (0.52) ADH1BADH1CADH1AADH7CYP2C19
SCHEMBL26983698 0.74 CYP2C9 (0.60) ADH1BADH1CADH1AADH7CYP2C19
SCHEMBL7449229 0.74 ADH1B (0.52) ADH1BADH1CADH1AADH7CYP2C19
SCHEMBL28831666 0.73 GAA (0.45) ADH1BADH1CADH1AADH7CYP2C19
SCHEMBL23620721 0.71 ADH1B (0.48) ADH1BADH1CADH1AADH7CYP2C19
Trifluoroacetic Acid SCHEMBL1191360 0.71 HDAC3 (0.60) CES1HDAC3HDAC4HDAC1HDAC6
Trifluoroacetic Acid SCHEMBL27999393 0.71 CES1 (0.53) CES1HDAC3HDAC4HDAC1HDAC6
SCHEMBL20344487 0.70 ADH1B (0.52) ADH1BADH1CADH1AADH7CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114988975-A Preparation method of beta-trifluoromethyl enamine compound based on organic dye catalysis 江苏科技大学 2022-09-02 CN disclosed