SCHEMBL28952116

SCHEMBL28952116

O=C1C[C@@H]2C[C@@H](Nc3c([N+](=O)[O-])cnc4c3ccn4S(=O)(=O)c3ccccc3)C[C@@H]2C1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.36
KMT2A Q03164 2/20 0.36
CYP2C19 P33261 1/20 0.34
HTR6 P50406 6/20 0.34
DRD2 P14416 1/20 0.34
DRD3 P35462 1/20 0.34
MET P08581 2/20 0.34
GAA P10253 4/20 0.33
MAPT P10636 3/20 0.33
LMNA P02545 2/20 0.33
HTT P42858 2/20 0.33
POLB P06746 1/20 0.32
PKM P14618 1/20 0.32
GPR174 Q9BXC1 2/20 0.32
NPC1 O15118 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
NOD1 Q9Y239 1/20 0.32
MEN1 O00255 1/20 0.32
MMP2 P08253 1/20 0.31
ANPEP P15144 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28952121 1.00 ALDH1A1 (0.36) ALDH1A1KMT2ACYP2C19HTR6DRD2
SCHEMBL28951942 0.91 ALDH1A1 (0.35) ALDH1A1KMT2ACYP2C19HTR6DRD2
SCHEMBL28951944 0.91 ALDH1A1 (0.35) ALDH1A1KMT2ACYP2C19HTR6DRD2
SCHEMBL29711840 0.91 ALDH1A1 (0.35) ALDH1A1KMT2ACYP2C19HTR6DRD2
SCHEMBL28952481 0.89 HTR6 (0.35) ALDH1A1KMT2ACYP2C19HTR6DRD2
SCHEMBL29711965 0.89 HTR6 (0.35) ALDH1A1KMT2ACYP2C19HTR6DRD2
SCHEMBL28952483 0.89 HTR6 (0.35) ALDH1A1KMT2ACYP2C19HTR6DRD2
SCHEMBL31601186 0.88 GSK3A (0.37) ALDH1A1KMT2ACYP2C19HTR6DRD2
SCHEMBL2273831 0.85 PDE4B (0.40) ALDH1A1KMT2ACYP2C19HTR6MET
SCHEMBL30368521 0.85 PDE4B (0.40) ALDH1A1KMT2ACYP2C19HTR6MET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114591321-A Aza-and-cyclic compounds, method for the production thereof and use thereof 广州费米子科技有限责任公司 2022-06-07 CN disclosed