Sugi Predict

Sugi Predict / Compounds / SCHEMBL289547

SCHEMBL289547

SCHEMBL289547

Cc1cc(C#N)ccc1C(=O)Cl

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ LRRK2 Q5S007 1/20 0.44
▸ CA1 P00915 2/20 0.41
▸ CA2 P00918 2/20 0.41
▸ MEN1 O00255 2/20 0.40
▸ KMT2A Q03164 2/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.39
▸ MRGPRX4 Q96LA9 1/20 0.39
▸ ALDH1A1 P00352 3/20 0.39
▸ CYP2A6 P11509 1/20 0.39
▸ FLT1 P17948 1/20 0.38
▸ FLT4 P35916 1/20 0.38
▸ KDR P35968 1/20 0.38
▸ FFAR1 O14842 1/20 0.38
▸ GSK3B P49841 2/20 0.38
▸ AR P10275 2/20 0.37
▸ XDH P47989 1/20 0.37
▸ SLC22A12 Q96S37 1/20 0.37
▸ NOTUM Q6P988 1/20 0.37
▸ PKM P14618 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26582862 0.85 FFAR1 (0.41) LRRK2CA1CA2MEN1KMT2A
SCHEMBL289026 0.83 XDH (0.49) LRRK2CA1CA2MRGPRX4FFAR1
SCHEMBL3361866 0.83 LRRK2 (0.48) LRRK2CA1CA2MEN1KMT2A
SCHEMBL26019644 0.82 LRRK2 (0.42) LRRK2CA1CA2L3MBTL1MRGPRX4
SCHEMBL2965097 0.81 PARP15 (0.46) LRRK2CA1CA2MRGPRX4ALDH1A1
SCHEMBL29360911 0.81 PARP15 (0.46) LRRK2CA1CA2MRGPRX4ALDH1A1
SCHEMBL10411914 0.81 ACACB (0.34) LRRK2ALDH1A1FLT1FLT4KDR
SCHEMBL6628485 0.79 FLT1 (0.52) CA1CA2MRGPRX4ALDH1A1FLT1
SCHEMBL28575929 0.79 CA1 (0.42) CA1CA2MEN1KMT2AALDH1A1
SCHEMBL13270694 0.79 LRRK2 (0.42) LRRK2CA1CA2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260092074-A1 Annelated Pyridines as Steroidogenesis Inhibitors, Preparation Method and Use Thereof GUANGZHOU VINNOCENT PHARMACEUTICAL LTD (CN) 2026-04-02 — — US disclosed
EP-4574830-A1 ANNELATED PYRIDINE STEROID SYNTHETASE INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF Guangzhou Vinnocent Pharmaceutical Limited (CN) 2025-06-25 — — EP disclosed
WO-2024089170-A1 ANTIBACTERIAL COMPOUNDS Janssen Sciences Ireland Unlimited Company (IE) 2024-05-02 — — WO disclosed
CN-116102493-A Amide compound and preparation method and application thereof 南通泰禾化工股份有限公司 2023-05-12 — — CN disclosed
WO-2023073090-A1 IMIDAZOPYRIDINE AMIDES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF BACTERIAL INFECTIONS Janssen Sciences Ireland Unlimited Company (IE) 2023-05-04 — — WO disclosed
WO-2022135447-A1 CYANO-SUBSTITUTED BENZAMIDE COMPOUND AND APPLICATION THEREOF 南通泰禾化工股份有限公司 2022-06-30 — — WO disclosed
CN-106242998-B Use of 4-cyano-3-benzoylamino-N-phenyl-benzamides in pesticides 先正达参股股份有限公司 2021-11-05 — — CN disclosed
CN-107683283-B BACE1 inhibitors 豪夫迈·罗氏有限公司 2021-05-18 — — CN disclosed
US-10696691-B2 BACE1 inhibitors HOFFMANN-LA ROCHE INC. (US) 2020-06-30 — — US disclosed
US-20190270757-A1 BACE1 INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2019-09-05 — — US disclosed
US-20110136875-A1 Pyrrole Inhibitors of S-Nitrosoglutathione Reductase N30 PHARMACEUTICALS, LLC (US) 2011-06-09 — — US disclosed
EP-2318007-A1 NOVEL PYRROLE INHIBITORS OF S-NITROSOGLUTATHIONE REDUCTASE AS THERAPEUTIC AGENTS N30 Pharmaceuticals, LLC (US) 2011-05-11 — — EP disclosed
EP-2315590-A1 PYRROLE INHIBITORS OF S-NITROSOGLUTATHIONE REDUCTASE N30 Pharmaceuticals, LLC (US) 2011-05-04 — — EP disclosed
WO-2010127928-A1 INSECTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2010-11-11 — — WO disclosed
WO-2010127926-A1 4 -CYANO- 3 -BENZOYLAMINO-N- PHENYL-BENZAMIDES FOR USE IN PEST CONTROL SYNGENTA PARTICIPATIONS AG (CH) 2010-11-11 — — WO disclosed
WO-2010019909-A1 PYRROLE INHIBITORS OF S-NITROSOGLUTATHIONE REDUCTASE N30 PHARMACEUTICALS, LLC (US) 2010-02-18 — — WO disclosed
WO-2010019909-A1 PYRROLE INHIBITORS OF S-NITROSOGLUTATHIONE REDUCTASE N30 PHARMACEUTICALS, LLC (US) 2010-02-18 — — WO disclosed
WO-2010019905-A1 NOVEL PYRROLE INHIBITORS OF S-NITROSOGLUTATHIONE REDUCTASE AS THERAPEUTIC AGENTS N30 PHARMACEUTICALS, LLC (US) 2010-02-18 — — WO disclosed
WO-2010019905-A1 NOVEL PYRROLE INHIBITORS OF S-NITROSOGLUTATHIONE REDUCTASE AS THERAPEUTIC AGENTS N30 PHARMACEUTICALS, LLC (US) 2010-02-18 — — WO disclosed
CN-1109050-A Catecholamine surrogates useful as beta3 agonists BRISTOL MYERS SQUIBB CO (US) 1995-09-27 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10696691-B2 BACE1 inhibitors BACE1, BACE2, APP LRRK2 405/4885CA1 744/4885CA2 3464/4885
US-20260092074-A1 Annelated Pyridines as Steroidogenesis Inhibitors, Preparation Method and Use Thereof STS, NR5A1, CYP21A2 LRRK2 4600/4885CA1 740/4885CA2 1669/4885
US-20110136875-A1 Pyrrole Inhibitors of S-Nitrosoglutathione Reductase GSR, GRHPR, POR LRRK2 1973/4885CA1 4318/4885CA2 3482/4885
US-20190270757-A1 BACE1 INHIBITORS BACE1, BACE2, APP LRRK2 405/4885CA1 744/4885CA2 3464/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.