Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 15/20 | 0.56 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.56 |
| ▸ | PTPRC | P08575 | 3/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CD69 | Q07108 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4859707 | 0.82 | LIMK1 (0.50) | PTPN1PTPN2LIMK1KDM4EALDH1A1 | |
| SCHEMBL11844857 | 0.78 | PTPN1 (0.76) | PTPN1PTPN2PTPRCKDM4EALDH1A1 | |
| SCHEMBL13926043 | 0.77 | KDM4E (0.71) | PTPN1PTPN2PTPRCHIF1ALIMK1 | |
| SCHEMBL3191306 | 0.77 | PTPN1 (0.52) | PTPN1PTPN2PTPRCHIF1AKDM4E | |
| SCHEMBL27404716 | 0.75 | LIMK1 (0.55) | LIMK1KDM4EALDH1A1KMT2A | |
| SCHEMBL10507045 | 0.75 | LIMK1 (0.55) | LIMK1KDM4EALDH1A1KMT2A | |
| SCHEMBL1098450 | 0.74 | LIMK1 (0.54) | PTPN1LIMK1KDM4EALDH1A1KMT2A | |
| SCHEMBL8507168 | 0.74 | LIMK1 (0.77) | LIMK1KDM4EALDH1A1KMT2A | |
| SCHEMBL4127206 | 0.74 | ALDH1A1 (0.46) | LIMK1KDM4EALDH1A1KMT2A | |
| SCHEMBL4129933 | 0.72 | CYP2C9 (0.58) | PTPN1PTPN2PTPRCKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | WYETH (US) | 2009-02-19 | — | — | US | disclosed |
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | WYETH (US) | 2009-02-19 | — | — | US | disclosed |
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | WYETH (US) | 2009-02-19 | — | — | US | disclosed |
| US-20050203081-A1 | Inhibitors of protein tyrosine phosphatase 1B | WYETH | 2005-09-15 | — | — | US | disclosed |
| WO-2005081960-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B | WYETH (US) | 2005-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203081-A1 | Inhibitors of protein tyrosine phosphatase 1B | PTPRS, PTPRO, PTPRM | PTPN1 11/4885PTPN2 23/4885PTPRC 13/4885 |
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | PTPRS, PTPRO, PTPRM | PTPN1 11/4885PTPN2 23/4885PTPRC 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.