SCHEMBL28958983

SCHEMBL28958983

CCOC(=O)CCC(=NO)c1ccc(C(F)(F)F)cc1

nearest known ligand 0.52

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.52
MAPT P10636 1/20 0.52
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
TRPM2 O94759 1/20 0.42
CYP1A1 P04798 2/20 0.42
CYP1B1 Q16678 2/20 0.42
MAOB P27338 1/20 0.42
PPARG P37231 4/20 0.42
PPARA Q07869 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
EPHX2 P34913 2/20 0.41
CES2 O00748 1/20 0.41
CES1 P23141 1/20 0.41
PTPN1 P18031 1/20 0.40
GSK3B P49841 1/20 0.40
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6158815 0.84 MAPT (0.44) ALDH1A1MAPTSMN1; SMN2NPSR1KMT2A
SCHEMBL6157301 0.84 MAPT (0.44) ALDH1A1MAPTSMN1; SMN2NPSR1KMT2A
SCHEMBL6158810 0.84 MAPT (0.44) ALDH1A1MAPTSMN1; SMN2NPSR1KMT2A
SCHEMBL28958971 0.84 NLRP3 (0.46) ALDH1A1MAPTSMN1; SMN2KMT2A
SCHEMBL9413505 0.82 ALDH1A1 (0.65) ALDH1A1MAPTNPC1RAB9ASMN1; SMN2
SCHEMBL28959008 0.81 SMN1; SMN2 (0.47) ALDH1A1MAPTNPC1RAB9ASMN1; SMN2
SCHEMBL28958998 0.81 KMT2A (0.51) ALDH1A1MAPTSMN1; SMN2MAOBNPSR1
SCHEMBL28959007 0.81 SMN1; SMN2 (0.51) ALDH1A1MAPTNPC1RAB9ASMN1; SMN2
SCHEMBL28958973 0.80 MAPT (0.48) ALDH1A1MAPTNPC1RAB9AKMT2A
SCHEMBL8541001 0.80 SMN1; SMN2 (0.53) ALDH1A1MAPTSMN1; SMN2CES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114621115-A Method for synthesizing oxime compound under photocatalysis condition 河南大学 2022-06-14 CN disclosed