Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Propionic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 2/20 | 0.67 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.47 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.47 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.47 |
| ▸ | GABRR1 | P24046 | 5/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.43 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.43 |
| ▸ | GABRP | O00591 | 1/20 | 0.43 |
| ▸ | GABRD | O14764 | 1/20 | 0.43 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propionic Acid SCHEMBL29198011 | 1.00 | FFAR3 (0.67) | FFAR3GLRA1SLC6A9OR51E2GABRR1 | |
| Propionic Acid SCHEMBL219329 | 0.97 | FFAR3 (0.71) | FFAR3GLRA1SLC6A9OR51E2GABRR1 | |
| Propionic Acid SCHEMBL10877398 | 0.97 | FFAR3 (0.71) | FFAR3GLRA1SLC6A9OR51E2GABRR1 | |
| Propionic Acid SCHEMBL5711851 | 0.97 | — | — | |
| Propionic Acid SCHEMBL10878598 | 0.97 | FFAR3 (0.71) | FFAR3GLRA1SLC6A9OR51E2GABRR1 | |
| Propionic Acid SCHEMBL452287 | 0.97 | FFAR3 (0.71) | FFAR3GLRA1SLC6A9OR51E2GABRR1 | |
| Propionic Acid SCHEMBL242079 | 0.93 | FFAR3 (0.67) | FFAR3GLRA1SLC6A9OR51E2GABRR1 | |
| Propionic Acid SCHEMBL2463993 | 0.93 | FFAR3 (0.67) | FFAR3GLRA1SLC6A9OR51E2GABRR1 | |
| Propionic Acid SCHEMBL8646907 | 0.90 | FFAR3 (0.62) | FFAR3GLRA1SLC6A9OR51E2GABRR1 | |
| Propionic Acid SCHEMBL29012488 | 0.90 | FFAR3 (0.62) | FFAR3GLRA1SLC6A9OR51E2GABRR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113072832-B | Combined rheology modifier and preparation method and application thereof | 万华化学集团股份有限公司 | 2023-03-03 | — | — | CN | claimed |
| CN-113072832-B | Combined rheology modifier and preparation method and application thereof | 万华化学集团股份有限公司 | 2023-03-03 | — | — | CN | disclosed |