Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NNMT | P40261 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23147047 | 0.75 | MAPT (0.39) | MAPTLMNANNMTALDH1A1HPGD | |
| SCHEMBL23147051 | 0.75 | MAPT (0.39) | MAPTLMNANNMTALDH1A1HPGD | |
| SCHEMBL18013429 | 0.75 | MAPT (0.50) | MAPTLMNAALDH1A1HPGDTDP1 | |
| SCHEMBL25339663 | 0.71 | NNMT (0.47) | NNMTALDH1A1SIRT6KMT2AGAA | |
| SCHEMBL14905497 | 0.71 | MAPT (0.36) | MAPTLMNANNMTALDH1A1HPGD | |
| SCHEMBL29764694 | 0.71 | MAPT (0.36) | MAPTLMNANNMTALDH1A1HPGD | |
| SCHEMBL20798617 | 0.69 | MAPT (0.44) | MAPTLMNAALDH1A1HPGDTDP1 | |
| SCHEMBL22712739 | 0.69 | NPC1 (0.40) | MAPTLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL22712738 | 0.69 | NPC1 (0.40) | MAPTLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL20798621 | 0.68 | HTT (0.48) | MAPTLMNAALDH1A1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115605478-A | Compounds and methods of use | 埃克塞里艾克西斯公司（US） | 2023-01-13 | — | — | CN | disclosed |
| CN-114787144-A | Pyridone compounds and methods for modulating protein kinases | 埃克塞里艾克西斯公司 | 2022-07-22 | — | — | CN | disclosed |