Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 5/20 | 0.47 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | BPTF | Q12830 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.34 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KLK3 | P07288 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21830618 | 0.77 | NNMT (0.47) | NNMTSIRT6MKNK1MKNK2MEN1 | |
| SCHEMBL28328451 | 0.77 | SIRT6 (0.38) | NNMTSIRT6MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16115684 | 0.73 | MEN1 (0.37) | NNMTBPTFMEN1PABPC1KMT2A | |
| SCHEMBL9572460 | 0.72 | MEN1 (0.36) | NNMTSIRT6MKNK1MKNK2MEN1 | |
| SCHEMBL17541475 | 0.71 | TUBB4A (0.34) | NNMTP2RX3P2RX2 | |
| SCHEMBL17131059 | 0.71 | NNMT (0.51) | NNMTSIRT6MEN1PABPC1KMT2A | |
| SCHEMBL16114745 | 0.71 | P2RX3 (0.37) | NNMTP2RX3P2RX2 | |
| SCHEMBL28966263 | 0.71 | MAPT (0.45) | NNMTSIRT6MEN1KMT2APOLB | |
| SCHEMBL28892575 | 0.71 | NNMT (0.41) | NNMTSIRT6SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL16936117 | 0.71 | DYRK1A (0.35) | NNMTSIRT6MKNK1MKNK2BPTF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117730083-A | Pyrimidine compounds as MAP4K1 inhibitors | 格兰马克专业公司 | 2024-03-19 | — | — | CN | disclosed |
| US-20230227483-A1 | PYRIMIDINE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS | GLENMARK SPECIALITY S.A. (CH) | 2023-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230227483-A1 | PYRIMIDINE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS | MAP4K1, MAP3K4, MAP4K2 | NNMT 308/4885SIRT6 1339/4885MKNK1 43/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.