Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | PRKCI | P41743 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.30 |
| ▸ | VHL | P40337 | 1/20 | 0.30 |
| ▸ | ELOC | Q15369 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30437990 | 1.00 | HPGD (0.41) | HPGDKDM4EALDH1A1HSD17B1MAPT | |
| SCHEMBL22253606 | 0.89 | MAOA (0.41) | HPGDKDM4EALDH1A1HSD17B1MAPT | |
| SCHEMBL1339423 | 0.79 | NOTUM (0.44) | HPGDKDM4EALDH1A1HSD17B1CASP1 | |
| SCHEMBL30666511 | 0.79 | NOTUM (0.44) | HPGDKDM4EALDH1A1HSD17B1CASP1 | |
| SCHEMBL8557216 | 0.79 | NOTUM (0.44) | HPGDKDM4EALDH1A1MAPTCASP1 | |
| SCHEMBL5740876 | 0.76 | KDM4E (0.41) | HPGDKDM4EALDH1A1HSD17B1CASP1 | |
| SCHEMBL17604845 | 0.76 | KDM4E (0.41) | HPGDKDM4EALDH1A1HSD17B1MAPT | |
| SCHEMBL11663902 | 0.76 | KDM4E (0.41) | HPGDKDM4EALDH1A1HSD17B1MAPT | |
| SCHEMBL22102587 | 0.76 | KDM4E (0.41) | HPGDKDM4EALDH1A1HSD17B1MAPT | |
| SCHEMBL19950131 | 0.76 | HSD17B1 (0.47) | HPGDKDM4EALDH1A1HSD17B1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115697995-A | Aminopyrimidinamides | 豪夫迈·罗氏有限公司 | 2023-02-03 | — | — | CN | disclosed |