SCHEMBL2897205

SCHEMBL2897205

O=C(O)Nc1nocc1C[C@@H]1CN(c2cc(F)c(I)c(F)c2)C(=O)O1

nearest known ligand 0.40

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MAOA P21397 7/20 0.40
CALML3 P27482 5/20 0.38
GRM2 Q14416 1/20 0.36
MAOB P27338 4/20 0.36
LMNA P02545 1/20 0.36
PTGS1 P23219 1/20 0.36
SDHA P31040 1/20 0.36
F10 P00742 3/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2896944 0.78 KDM4E (0.37) MAOACALML3MAOB
SCHEMBL2897104 0.76 MAOA (0.47) MAOACALML3MAOB
SCHEMBL5899044 0.73 MAOA (0.43) MAOACALML3MAOBLMNAPTGS1
SCHEMBL2890864 0.73 CALML3 (0.59) MAOACALML3MAOBLMNAPTGS1
SCHEMBL2898104 0.73 CALML3 (0.59) MAOACALML3MAOBLMNAPTGS1
SCHEMBL8590619 0.71 MAOA (0.64) MAOACALML3MAOBLMNAPTGS1
SCHEMBL2891482 0.71 MAOA (0.64) MAOACALML3MAOBLMNAPTGS1
SCHEMBL3187054 0.71 MAOA (0.64) MAOACALML3MAOBLMNAPTGS1
SCHEMBL12956131 0.70 F10 (0.49) MAOACALML3GRM2MAOBF10
SCHEMBL16786670 0.70 GRM2 (0.46) MAOACALML3GRM2MAOBLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100286211-A1 OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS RANBAXY LABORATORIES LIMITED (IN) 2010-11-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100286211-A1 OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS OXA1L, PDK4, MLYCD MAOA 1717/4885CALML3 3047/4885GRM2 3646/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.