SCHEMBL28973166

SCHEMBL28973166

CC(C)(C)OC(=O)CN1CCNC[C@@H]1C(F)(F)F

nearest known ligand 0.34

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 1/20 0.34
PLA2G10 O15496 1/20 0.33
PLA2G5 P39877 1/20 0.33
PARP1 P09874 1/20 0.32
HTR2A P28223 1/20 0.32
HTR2C P28335 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30403488 0.86 GRM2 (0.35) GRM2HTR2AHTR2C
SCHEMBL29170253 0.86 GRM2 (0.35) GRM2HTR2AHTR2C
SCHEMBL29170258 0.86 GRM2 (0.35) GRM2HTR2AHTR2C
SCHEMBL30663182 0.83 CYP1A2 (0.34) GRM2HTR2AHTR2C
SCHEMBL30663148 0.83 CYP1A2 (0.34) GRM2HTR2AHTR2C
SCHEMBL17152994 0.81 PLA2G10 (0.35) PLA2G10PLA2G5PARP1
Trifluoroacetic Acid SCHEMBL30403192 0.81 PKM (0.38) GRM2HTR2AHTR2C
SCHEMBL28973143 0.81 GRM2 (0.34) GRM2
SCHEMBL28973233 0.79 GRM2 (0.37) GRM2HTR2AHTR2C
SCHEMBL28973118 0.79 GRM2 (0.37) GRM2HTR2AHTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115968293-A Cereblon binding compounds, compositions thereof, and methods of use thereof for treatment 新基公司 2023-04-14 CN disclosed
CN-115955979-A Cereblan binding compounds, compositions thereof, and methods for treatment thereof 新基公司 2023-04-11 CN disclosed
CN-115835866-A Cereblon binding compounds, compositions thereof, and methods of use thereof for treatment 新基公司 2023-03-21 CN disclosed