SCHEMBL28974065

SCHEMBL28974065

COC(=O)c1ccc(C2CCC2)c(I)c1C1CCC1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 7/20 0.38
ALDH1A1 P00352 7/20 0.38
PDK2 Q15119 2/20 0.38
PDK4 Q16654 2/20 0.38
HSD17B10 Q99714 3/20 0.37
NPSR1 Q6W5P4 2/20 0.37
HPGD P15428 2/20 0.37
RIPK1 Q13546 1/20 0.36
TSHR P16473 3/20 0.35
DRD2 P14416 1/20 0.35
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA7 P43166 1/20 0.35
CA9 Q16790 1/20 0.35
CA14 Q9ULX7 1/20 0.35
MAPT P10636 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
MEN1 O00255 1/20 0.35
HTT P42858 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30281107 0.81 KDM4E (0.45) KDM4EALDH1A1HSD17B10NPSR1HPGD
SCHEMBL11566905 0.79 KDM4E (0.50) KDM4EALDH1A1HSD17B10NPSR1HPGD
SCHEMBL28974087 0.77 KDM4E (0.38) KDM4EALDH1A1PDK2PDK4HSD17B10
SCHEMBL5951054 0.77 CA12 (0.46) KDM4EALDH1A1PDK2PDK4HSD17B10
SCHEMBL30009936 0.76 CXCR5 (0.50) KDM4EALDH1A1HSD17B10NPSR1HPGD
SCHEMBL15648565 0.73 KDM4E (0.51) KDM4EALDH1A1PDK2PDK4HSD17B10
SCHEMBL12488847 0.73 PTGDR2 (0.48) KDM4EALDH1A1PDK2PDK4HSD17B10
SCHEMBL30280770 0.73 HSP90AA1 (0.48) KDM4EALDH1A1PDK2PDK4HSD17B10
SCHEMBL17669997 0.73 HSP90AA1 (0.48) KDM4EALDH1A1PDK2PDK4HSD17B10
SCHEMBL30425639 0.73 PTGER4 (0.44) KDM4EALDH1A1PDK2PDK4HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116139138-A Heterocyclic modulators of lipid synthesis 3-V生物科学股份有限公司 2023-05-23 CN disclosed
CN-110177551-B Heterocyclic modulators of lipid synthesis 3-V生物科学股份有限公司 2023-02-17 CN disclosed