Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 8/20 | 0.40 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.38 |
| ▸ | UGCG | Q16739 | 4/20 | 0.38 |
| ▸ | GBA2 | Q9HCG7 | 4/20 | 0.38 |
| ▸ | GBA1 | P04062 | 3/20 | 0.38 |
| ▸ | LCT | P09848 | 3/20 | 0.38 |
| ▸ | MGAM | O43451 | 2/20 | 0.38 |
| ▸ | SI | P14410 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL30280461 | 0.73 | IGF1R (0.47) | CHRNA7 | |
| Bromide SCHEMBL28974248 | 0.73 | IGF1R (0.47) | CHRNA7 | |
| Bromide SCHEMBL30457991 | 0.72 | IGF1R (0.63) | TRAP1 | |
| Bromide SCHEMBL29040474 | 0.72 | IGF1R (0.63) | TRAP1 | |
| Bromide SCHEMBL11349324 | 0.72 | CHRNA7 (0.46) | CHRNA7TRAP1 | |
| Bromide SCHEMBL30061989 | 0.70 | HDAC3 (0.45) | — | |
| Bromide SCHEMBL28907465 | 0.70 | HDAC3 (0.45) | — | |
| Bromide SCHEMBL52420 | 0.69 | HIF1A (0.70) | CHRNA7TRAP1 | |
| Bromide SCHEMBL2450121 | 0.69 | HIF1A (0.70) | CHRNA7TRAP1 | |
| Bromide SCHEMBL4184421 | 0.69 | HIF1A (0.70) | CHRNA7TRAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115850334-A | Triphenylphosphonium-hydroxytyrosol, synthesis method thereof and application thereof in preparing drugs for inhibiting cancer cell proliferation | 西安交通大学 | 2023-03-28 | — | — | CN | disclosed |