Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.49 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.47 |
| ▸ | IGF1R | P08069 | 7/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 7/20 | 0.63 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL30457991 | 1.00 | IGF1R (0.63) | IGF1RALOX15ADRB2ADORA3CHRM1 | |
| Bromide SCHEMBL30280461 | 0.86 | IGF1R (0.47) | IGF1RALOX15ADRB2ADORA3CHRM1 | |
| Bromide SCHEMBL28974248 | 0.86 | IGF1R (0.47) | IGF1RALOX15ADRB2ADORA3CHRM1 | |
| Bromide SCHEMBL10996214 | 0.80 | HIF1A (0.54) | TRAP1MAPT | |
| Bromide SCHEMBL9442232 | 0.80 | HIF1A (0.54) | TRAP1MAPT | |
| Bromide SCHEMBL15766394 | 0.80 | HIF1A (0.54) | TRAP1MAPT | |
| Bromide SCHEMBL27200165 | 0.79 | TRAP1 (0.53) | IGF1RALOX15TRAP1 | |
| Bromide SCHEMBL30132764 | 0.79 | TRAP1 (0.53) | IGF1RALOX15TRAP1 | |
| Bromide SCHEMBL3042031 | 0.78 | HIF1A (0.56) | TRAP1ALDH1A1 | |
| SCHEMBL2306276 | 0.78 | ALOX15 (1.00) | IGF1RALOX15ADRB2ADORA3CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116444569-A | Triphenylhydroxytyrosol and synthesis method thereof and application of triphenylhydroxytyrosol in preparation of medicines for improving aortic endothelial cell functions | 西安交通大学 | 2023-07-18 | — | — | CN | disclosed |