Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.50 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8809751 | 0.80 | KMT2A (1.00) | MEN1KMT2AALDH1A1USP2LMNA | |
| SCHEMBL4306902 | 0.80 | KMT2A (1.00) | MEN1KMT2AALDH1A1USP2LMNA | |
| SCHEMBL4306904 | 0.80 | KMT2A (1.00) | MEN1KMT2AALDH1A1USP2LMNA | |
| SCHEMBL17750100 | 0.78 | MEN1 (0.69) | MEN1KMT2AUSP2LMNAALOX15 | |
| SCHEMBL3304132 | 0.78 | ALDH2 (0.47) | MEN1KMT2AALDH2ALDH1A3ALOX15 | |
| SCHEMBL2144787 | 0.78 | ALDH2 (0.47) | MEN1KMT2AALDH2ALDH1A3ALOX15 | |
| SCHEMBL3304135 | 0.78 | ALDH2 (0.47) | MEN1KMT2AALDH2ALDH1A3ALOX15 | |
| SCHEMBL24758381 | 0.77 | ALDH2 (0.46) | MEN1KMT2AALDH2ALDH1A3ESR1 | |
| SCHEMBL28905087 | 0.77 | DGAT1 (0.52) | MEN1KMT2AALDH2ALDH1A3ALDH1A1 | |
| SCHEMBL332423 | 0.76 | ALDH1A1 (0.50) | MEN1KMT2AALDH1A1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115867535-B | Substituted benzamides as modulators of TREX1 | 星座制药公司 | 2024-12-17 | — | — | CN | disclosed |
| EP-4157821-A1 | SUBSTITUTED BENZAMIDES AS MODULATORS OF TREX1 | Constellation Pharmaceuticals, Inc. (US) | 2023-04-05 | — | — | EP | disclosed |
| CN-115867535-A | Substituted benzamides as modulators of TREX1 | 星座制药公司 | 2023-03-28 | — | — | CN | disclosed |