SCHEMBL2897678

SCHEMBL2897678

CNC(=S)NC[C@H]1CN(c2cc(F)c(-c3ccc(-n4cncn4)nc3)c(F)c2)C(=O)O1

nearest known ligand 0.41

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MAOA P21397 6/20 0.40
F10 P00742 4/20 0.40
CALML3 P27482 4/20 0.39
MAOB P27338 4/20 0.39
LMNA P02545 1/20 0.39
PTGS1 P23219 1/20 0.39
SDHA P31040 1/20 0.39
CYP2C19 P33261 2/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C9 P11712 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2890869 0.92 MAOA (0.43) MAOAF10CALML3MAOBLMNA
SCHEMBL2896788 0.91 F10 (0.40) MAOAF10CALML3MAOBLMNA
SCHEMBL2896279 0.90 MAOA (0.51) MAOAF10CALML3MAOBLMNA
SCHEMBL2890769 0.89 MAOA (0.44) MAOAF10CALML3MAOBLMNA
SCHEMBL5220387 0.86 MAOA (0.45) MAOACYP3A4CYP2C9
SCHEMBL2890867 0.84 CALML3 (0.40) MAOACALML3MAOBCYP2C19CYP3A4
SCHEMBL5223015 0.84 CALML3 (0.42) MAOAF10CALML3MAOBCYP2C19
SCHEMBL2890506 0.84 CALML3 (0.42) MAOAF10CALML3MAOBCYP2C19
SCHEMBL5223010 0.82 KDM4E (0.39) MAOACALML3MAOBCYP2C19CYP3A4
SCHEMBL2890683 0.82 CALML3 (0.39) MAOACALML3MAOBCYP2C19CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100286211-A1 OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS RANBAXY LABORATORIES LIMITED (IN) 2010-11-11 US claimed
US-20100286211-A1 OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS RANBAXY LABORATORIES LIMITED (IN) 2010-11-11 US disclosed
EP-1799677-A1 OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS Ranbaxy Laboratories Limited (IN) 2007-06-27 EP disclosed
WO-2006038100-A1 OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS RANBAXY LABORATORIES LIMITED (IN) 2006-04-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100286211-A1 OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS OXA1L, PDK4, MLYCD MAOA 1717/4885F10 1709/4885CALML3 3047/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.