Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 18/20 | 0.64 |
| ▸ | RXRB | P28702 | 4/20 | 0.47 |
| ▸ | RXRG | P48443 | 4/20 | 0.47 |
| ▸ | RARA | P10276 | 4/20 | 0.47 |
| ▸ | RARB | P10826 | 4/20 | 0.47 |
| ▸ | RARG | P13631 | 4/20 | 0.47 |
| ▸ | HNF4A | P41235 | 2/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.39 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6910130 | 0.91 | RXRA (0.62) | RXRARXRBRXRGRARARARB | |
| SCHEMBL872423 | 0.88 | RXRA (0.61) | RXRARXRBRXRGRARARARB | |
| SCHEMBL29395963 | 0.88 | RXRA (0.61) | RXRARXRBRXRGRARARARB | |
| Acetic Acid SCHEMBL5879410 | 0.85 | RXRA (0.62) | RXRARXRBRXRGRARARARB | |
| SCHEMBL6668009 | 0.82 | RXRA (0.47) | RXRARXRBRXRGRARARARB | |
| SCHEMBL8853218 | 0.82 | RXRA (0.46) | RXRARXRBRXRGRARARARB | |
| SCHEMBL12418596 | 0.80 | RXRA (0.50) | RXRARXRBRXRGRARARARB | |
| SCHEMBL1269026 | 0.79 | RXRA (1.00) | RXRARXRBRXRGRARARARB | |
| SCHEMBL6679884 | 0.77 | RXRA (0.64) | RXRARXRBRXRGRARARARB | |
| SCHEMBL6916396 | 0.77 | RXRA (1.00) | RXRARXRBRXRGRARARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968602-B2 | 4-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-napthalenyl)-1-propenyl]benzoic acid analogs and method of manufacture and use thereof | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2011-06-28 | — | — | US | disclosed |
| US-7968602-B2 | 4-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-napthalenyl)-1-propenyl]benzoic acid analogs and method of manufacture and use thereof | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2011-06-28 | — | — | US | disclosed |
| US-20100029777-A1 | 4-[(E)-2-(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPTHALENYL)-1-PROPENYL]BENZOIC ACID ANALOGS AND METHOD OF MANUFACTURE AND USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-02-04 | — | — | US | disclosed |
| US-20100029777-A1 | 4-[(E)-2-(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPTHALENYL)-1-PROPENYL]BENZOIC ACID ANALOGS AND METHOD OF MANUFACTURE AND USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-02-04 | — | — | US | disclosed |
| US-7585894-B2 | 4-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-napthalenyl)-1-propenyl]benzoic acid analogs and method of manufacture and use thereof | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2009-09-08 | — | — | US | disclosed |
| US-7585894-B2 | 4-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-napthalenyl)-1-propenyl]benzoic acid analogs and method of manufacture and use thereof | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2009-09-08 | — | — | US | disclosed |
| EP-1896392-A1 | A-[E)-2-(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPTHALENYL)-1-PROPENYL]BENZOIC ACID ANALOGS AND METHOD OF MANUFACTURE AND AND USE THEREOF | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2008-03-12 | — | — | EP | disclosed |
| US-20070015717-A1 | 4-[(E)-2-(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPTHALENYL)-1-PROPENYL]BENZOIC ACID ANALOGS AND METHOD OF MANUFACTURE AND USE THEREOF | UNIVERSITY OF CALIFORNIA-LOS ANGELES | 2007-01-18 | — | — | US | disclosed |
| US-20070015717-A1 | 4-[(E)-2-(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPTHALENYL)-1-PROPENYL]BENZOIC ACID ANALOGS AND METHOD OF MANUFACTURE AND USE THEREOF | UNIVERSITY OF CALIFORNIA-LOS ANGELES | 2007-01-18 | — | — | US | disclosed |
| WO-2007005568-A1 | A-[(E)-2-(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPTHALENYL)-1-PROPENYL]BENZOIC ACID ANALOGS AND METHOD OF MANUFACTURE AND AND USE THEREOF | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2007-01-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029777-A1 | 4-[(E)-2-(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPTHALENYL)-1-PROPENYL]BENZOIC ACID ANALOGS AND METHOD OF MANUFACTURE AND USE THEREOF | BRCA1, TTPA, UGT2B7 | RXRA 566/4885RXRB 773/4885RXRG 636/4885 |
| US-20070015717-A1 | 4-[(E)-2-(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPTHALENYL)-1-PROPENYL]BENZOIC ACID ANALOGS AND METHOD OF MANUFACTURE AND USE THEREOF | BRCA1, TTPA, UGT2B7 | RXRA 566/4885RXRB 773/4885RXRG 636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.