Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.51 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.46 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.46 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.46 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.43 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL30335781 | 1.00 | GSR (0.51) | GSRGNAI3GNAO1GNAI1GRIK1 | |
| Lysine SCHEMBL27895871 | 1.00 | GSR (0.51) | GSRGNAI3GNAO1GNAI1GRIK1 | |
| Lysine SCHEMBL29981026 | 1.00 | GSR (0.51) | GSRGNAI3GNAO1GNAI1GRIK1 | |
| Lysine SCHEMBL27898144 | 0.95 | GSR (0.54) | GSRGNAI3GNAO1GNAI1GRIK1 | |
| D-Glutamate SCHEMBL28979836 | 0.87 | GRIK1 (0.46) | GSRGRIK1GRIK2SLC1A2SLC1A1 | |
| D-Glutamate SCHEMBL29211693 | 0.87 | GRIK1 (0.46) | GSRGRIK1GRIK2SLC1A2SLC1A1 | |
| Glutamic Acid SCHEMBL30335559 | 0.87 | GRIK1 (0.46) | GSRGRIK1GRIK2SLC1A2SLC1A1 | |
| D-Glutamate SCHEMBL27881574 | 0.87 | GRIK1 (0.46) | GSRGRIK1GRIK2SLC1A2SLC1A1 | |
| Serine SCHEMBL28601534 | 0.87 | GRIK1 (0.42) | GRIK1GRIK2SLC1A2SLC1A1DPP7 | |
| Serine SCHEMBL28979839 | 0.87 | GRIK1 (0.42) | GRIK1GRIK2SLC1A2SLC1A1DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115888179-A | Method for separating ruscogenin epimers by adopting ionic liquid body fluid-liquid extraction | 中国药科大学 | 2023-04-04 | — | — | CN | claimed |
| CN-115888179-A | Method for separating ruscogenin epimers by adopting ionic liquid body fluid-liquid extraction | 中国药科大学 | 2023-04-04 | — | — | CN | disclosed |
| CN-115888179-A | Method for separating ruscogenin epimers by adopting ionic liquid body fluid-liquid extraction | 中国药科大学 | 2023-04-04 | — | — | CN | disclosed |