Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 11/20 | 0.73 |
| ▸ | MAP3K7 | O43318 | 6/20 | 0.68 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.68 |
| ▸ | SRC | P12931 | 2/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.68 |
| ▸ | BTK | Q06187 | 2/20 | 0.64 |
| ▸ | JAK2 | O60674 | 3/20 | 0.61 |
| ▸ | EGFR | P00533 | 3/20 | 0.61 |
| ▸ | BLK | P51451 | 3/20 | 0.61 |
| ▸ | BMX | P51813 | 1/20 | 0.61 |
| ▸ | FLT3 | P36888 | 3/20 | 0.61 |
| ▸ | JAK1 | P23458 | 3/20 | 0.60 |
| ▸ | TTK | P33981 | 2/20 | 0.60 |
| ▸ | TXK | P42681 | 1/20 | 0.57 |
| ▸ | ITK | Q08881 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17209773 | 0.91 | JAK3 (0.83) | JAK3MAP3K7MAP2K1SRCMAPK1 | |
| SCHEMBL28981003 | 0.91 | JAK3 (0.60) | JAK3MAP3K7MAP2K1SRCMAPK1 | |
| SCHEMBL28980965 | 0.88 | MAP3K7 (0.81) | JAK3MAP3K7MAP2K1SRCMAPK1 | |
| SCHEMBL18440651 | 0.85 | ALK (0.74) | JAK3MAP3K7SRCFGFR1JAK2 | |
| SCHEMBL17209811 | 0.84 | JAK3 (1.00) | JAK3BTKJAK2EGFRBLK | |
| SCHEMBL18501686 | 0.82 | JAK3 (0.85) | JAK3MAP3K7MAP2K1SRCMAPK1 | |
| SCHEMBL28981015 | 0.82 | JAK3 (0.69) | JAK3MAP3K7MAP2K1SRCMAPK1 | |
| SCHEMBL31684778 | 0.82 | BTK (0.80) | JAK3MAP3K7MAP2K1SRCMAPK1 | |
| SCHEMBL17209772 | 0.82 | JAK3 (1.00) | JAK3BTKJAK2EGFRJAK1 | |
| SCHEMBL28980968 | 0.82 | BTK (0.80) | JAK3MAP3K7MAP2K1SRCMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4617261-A1 | 2,4,5-TRISUBSTITUTED PYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | Wenzhou Medical University (CN) | 2025-09-17 | — | — | EP | claimed |
| CN-115894381-A | 2,4,5-trisubstituted pyrimidine compound and preparation method and application thereof | 温州医科大学 | 2023-04-04 | — | — | CN | claimed |
| EP-4617261-A1 | 2,4,5-TRISUBSTITUTED PYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | Wenzhou Medical University (CN) | 2025-09-17 | — | — | EP | disclosed |
| CN-115894381-A | 2,4,5-trisubstituted pyrimidine compound and preparation method and application thereof | 温州医科大学 | 2023-04-04 | — | — | CN | disclosed |