Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 10/20 | 0.60 |
| ▸ | BRD4 | O60885 | 2/20 | 0.58 |
| ▸ | FLT3 | P36888 | 2/20 | 0.58 |
| ▸ | EGFR | P00533 | 2/20 | 0.58 |
| ▸ | BLK | P51451 | 1/20 | 0.58 |
| ▸ | SRC | P12931 | 4/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.57 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.57 |
| ▸ | JAK1 | P23458 | 2/20 | 0.56 |
| ▸ | BTK | Q06187 | 3/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | TYK2 | P29597 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28981015 | 0.92 | JAK3 (0.69) | JAK3BRD4FLT3EGFRBLK | |
| SCHEMBL28980974 | 0.91 | JAK3 (0.73) | JAK3FLT3EGFRBLKSRC | |
| SCHEMBL28980992 | 0.89 | BRD4 (0.72) | JAK3BRD4FLT3EGFRBLK | |
| SCHEMBL31684784 | 0.82 | EGFR (0.72) | JAK3BRD4EGFRBLKSRC | |
| SCHEMBL28980983 | 0.82 | EGFR (0.72) | JAK3BRD4EGFRBLKSRC | |
| SCHEMBL17209773 | 0.82 | JAK3 (0.83) | JAK3FLT3EGFRBLKSRC | |
| SCHEMBL28980984 | 0.81 | SRC (0.82) | BRD4FLT3SRCFGFR1MAP3K7 | |
| SCHEMBL28980990 | 0.80 | SRC (0.69) | JAK3BRD4FLT3EGFRBLK | |
| SCHEMBL28980965 | 0.80 | MAP3K7 (0.81) | JAK3BRD4FLT3EGFRBLK | |
| SCHEMBL28940865 | 0.80 | BRD4 (0.62) | BRD4FLT3EGFRMAP3K7BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4617261-A1 | 2,4,5-TRISUBSTITUTED PYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | Wenzhou Medical University (CN) | 2025-09-17 | — | — | EP | claimed |
| WO-2024099168-A1 | 2,4,5-TRISUBSTITUTED PYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | 温州医科大学 | 2024-05-16 | — | — | WO | claimed |
| CN-115894381-A | 2,4,5-trisubstituted pyrimidine compound and preparation method and application thereof | 温州医科大学 | 2023-04-04 | — | — | CN | claimed |