Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1616135 | 0.75 | KMT2A (0.48) | ATMKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL1616101 | 0.75 | KMT2A (0.48) | ATMKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL1791429 | 0.75 | KDM4E (0.56) | KDM4ERXFP1MEN1KMT2AALDH1A1 | |
| SCHEMBL1616671 | 0.74 | MEN1 (0.49) | ATMKDM4ERXFP1MEN1KMT2A | |
| SCHEMBL27947679 | 0.73 | MAPK14 (0.47) | KDM4EGAAMAPTLMNAMERTK | |
| SCHEMBL2897916 | 0.73 | GLP1R (0.49) | KDM4EMEN1KMT2AALDH1A1HTT | |
| SCHEMBL7569823 | 0.72 | PTPN1 (0.67) | MEN1KMT2AKEAP1NFE2L2CHEK1 | |
| SCHEMBL27947673 | 0.72 | MAPK14 (0.48) | KDM4EMAPTLMNAMERTKADORA3 | |
| SCHEMBL2904674 | 0.71 | PKM (0.39) | KDM4ERXFP1MEN1KMT2AALDH1A1 | |
| SCHEMBL27947654 | 0.69 | MAPK14 (0.48) | KDM4ELMNAMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099763-B1 | 2-AMINOQUINOLINES AS 5-HT(5A) RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-08-11 | — | — | EP | disclosed |