Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.67 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.67 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.61 |
| ▸ | CDK8 | P49336 | 1/20 | 0.61 |
| ▸ | NEK2 | P51955 | 1/20 | 0.61 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.61 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.57 |
| ▸ | METAP2 | P50579 | 1/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7589375 | 0.85 | MEN1 (0.77) | KEAP1NFE2L2MEN1TSHRKMT2A | |
| SCHEMBL7577515 | 0.85 | SMN1; SMN2 (0.65) | PTPN1KEAP1MEN1TSHRKMT2A | |
| SCHEMBL7594942 | 0.83 | KEAP1 (0.62) | KEAP1NFE2L2MEN1TSHRKMT2A | |
| SCHEMBL7571483 | 0.82 | LMNA (0.67) | KEAP1NFE2L2MEN1TSHRKMT2A | |
| SCHEMBL7578880 | 0.81 | KEAP1 (0.76) | KEAP1NFE2L2MEN1TSHRKMT2A | |
| SCHEMBL7598878 | 0.81 | PTGES2 (0.62) | PTPN1MEN1KMT2A | |
| SCHEMBL7854392 | 0.80 | TSHR (0.70) | KEAP1NFE2L2MEN1TSHRKMT2A | |
| SCHEMBL7589428 | 0.80 | FFAR4 (0.67) | KEAP1NFE2L2MEN1TSHRKMT2A | |
| SCHEMBL7595505 | 0.80 | KEAP1 (0.59) | KEAP1NFE2L2MEN1TSHRKMT2A | |
| SCHEMBL7569763 | 0.79 | FFAR4 (0.59) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |