Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.80 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.80 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.80 |
| ▸ | HMGCR | P04035 | 5/20 | 0.77 |
| ▸ | RXRA | P19793 | 3/20 | 0.77 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | CCKAR | P32238 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30881627 | 1.00 | NR4A2 (0.80) | NR4A2PDE4DNR1I2HMGCRRXRA | |
| SCHEMBL3529615 | 1.00 | NR4A2 (0.80) | NR4A2PDE4DNR1I2HMGCRRXRA | |
| SCHEMBL14273685 | 1.00 | NR4A2 (0.80) | NR4A2PDE4DNR1I2HMGCRRXRA | |
| SCHEMBL30291805 | 1.00 | NR4A2 (0.80) | NR4A2PDE4DNR1I2HMGCRRXRA | |
| SCHEMBL30203740 | 1.00 | NR4A2 (0.80) | NR4A2PDE4DNR1I2HMGCRRXRA | |
| SCHEMBL14273684 | 1.00 | NR4A2 (0.80) | NR4A2PDE4DNR1I2HMGCRRXRA | |
| SCHEMBL10153166 | 1.00 | NR4A2 (0.80) | NR4A2PDE4DNR1I2HMGCRRXRA | |
| SCHEMBL2904607 | 1.00 | NR4A2 (0.80) | NR4A2PDE4DNR1I2HMGCRRXRA | |
| SCHEMBL1582433 | 1.00 | NR4A2 (0.80) | NR4A2PDE4DNR1I2HMGCRRXRA | |
| SCHEMBL1582437 | 1.00 | NR4A2 (0.80) | NR4A2PDE4DNR1I2HMGCRRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1623978-B1 | METHOD FOR PRODUCING ETHYL (3R, 5S, 6E)-7-[2-CYCLOPROPYL-4-( 4-FLUOROPHENYL)QUINOLINE-3-YL]-3,5-DIHYDROXY-6-HEPTENOATE | DAICEL CHEM (JP) | 2010-08-11 | — | — | EP | claimed |
| US-7550596-B2 | Method of producing ethyl (3R, 5S, 6E)-7-[2 cyclopropyl-4-(fluorophenyl) quinoline-3-yl]-3, 5-dihydroxy-6-heptenoate | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 2009-06-23 | — | — | US | claimed |
| CN-100408562-C | Method of producing ethyl (3r, 5s, 6e)-7-[2 cyclopropyl-4-(fluorophenyl) quinoline-3-yl]-3, 5-dihydroxy-6-heptenoate | NISSAN CHEMICAL IND LTD (JP) | 2008-08-06 | — | — | CN | claimed |
| CN-1809537-A | Method of producing ethyl (3r, 5s, 6e)-7-[2 cyclopropyl-4-(fluorophenyl) quinoline-3-yl]-3, 5-dihydroxy-6-heptenoate | NISSAN CHEMICAL IND LTD (JP) | 2006-07-26 | — | — | CN | claimed |
| US-20060089381-A1 | Method of producing Ethyl (3R, 5S, 6E)-7-[2 cyclopropyl-4-(fluorophenyl) quinoline-3-yl]-3, 5-dihydroxy-6-heptenoate | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 2006-04-27 | — | — | US | claimed |
| EP-1623978-A1 | METHOD FOR PRODUCING ETHYL (3R, 5S, 6E)-7- 2-CYCLOPROPYL-4-( 4-FLUOROPHENYL)QUINOLINE-3-YL -3,5-DIHYDROXY-6-HEPTENOATE | DAICEL CHEMICAL INDUSTRIES, Ltd. (JP) | 2006-02-08 | — | — | EP | claimed |
| US-6946557-B2 | Process for producing optically active ethyl (3R, 5S, 6E)-7-[2-cycloproply-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-6-heptenoate | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 2005-09-20 | — | — | US | claimed |
| US-20050075502-A1 | Process for producing optically active ethly (3r, 5s, 6e)-7- [2-cycloproply-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-6-heptenoate | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2005-04-07 | — | — | US | claimed |
| CN-1136183-C | Process for producing optically active mevalonolactone compound | ���ƻ�ѧ��ҵ��ʽ���� | 2004-01-28 | — | — | CN | claimed |
| EP-1334967-A1 | PROCESS FOR PRODUCIGN OPTICALLY ACTIVE ETHYL (3R,5S,6E)-7- 2-CYCLOPROPYL-4-(4-FLUOROPHENYL)QUINOLIN-3-YL]-3,5-DIHYDROXY-6-HEPTENOATE | Daicel Chemical Industries, Ltd. (JP) | 2003-08-13 | — | — | EP | claimed |
| EP-0747341-B1 | PROCESS FOR PRODUCING OPTICALLY ACTIVE MEVALONOLACTONE COMPOUNDS | DAICEL CHEM (JP) | 2002-05-22 | — | — | EP | claimed |
| US-5939552-A | RESOLUTION OF ENANTIOMORPHS WITH BATCH SYSTEM CHROMATOGRAPHY OR MOVING BED CHROMATOGRAPHY | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 1999-08-17 | — | — | US | claimed |
| CN-1141028-A | Process for producing optically active mevalonolactone compound | DAICEL CHEM (JP) | 1997-01-22 | — | — | CN | claimed |
| EP-0747341-A1 | PROCESS FOR PRODUCING OPTICALLY ACTIVE MEVALONOLACTONE COMPOUND | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 1996-12-11 | — | — | EP | claimed |
| EP-1623978-B1 | METHOD FOR PRODUCING ETHYL (3R, 5S, 6E)-7-[2-CYCLOPROPYL-4-( 4-FLUOROPHENYL)QUINOLINE-3-YL]-3,5-DIHYDROXY-6-HEPTENOATE | DAICEL CHEM (JP) | 2010-08-11 | — | — | EP | disclosed |
| US-7749389-B2 | Filler used for separating optical isomers and process for separating optical isomers with the filler | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 2010-07-06 | — | — | US | disclosed |
| CN-1845899-B | Process for producing high purity 3,5-dihydroxy-6-heptenoic acid derivative | NISSAN CHEMICAL IND LTD | 2010-04-28 | — | — | CN | disclosed |
| US-5939552-A | RESOLUTION OF ENANTIOMORPHS WITH BATCH SYSTEM CHROMATOGRAPHY OR MOVING BED CHROMATOGRAPHY | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 1999-08-17 | — | — | US | disclosed |
| CN-1141028-A | Process for producing optically active mevalonolactone compound | DAICEL CHEM (JP) | 1997-01-22 | — | — | CN | disclosed |
| EP-0747341-A1 | PROCESS FOR PRODUCING OPTICALLY ACTIVE MEVALONOLACTONE COMPOUND | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 1996-12-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060089381-A1 | Method of producing Ethyl (3R, 5S, 6E)-7-[2 cyclopropyl-4-(fluorophenyl) quinoline-3-yl]-3, 5-dihydroxy-6-heptenoate | UGT1A6, RPL6, CXCR6 | NR4A2 3641/4885PDE4D 666/4885NR1I2 3070/4885 |
| US-20050075502-A1 | Process for producing optically active ethly (3r, 5s, 6e)-7- [2-cycloproply-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-6-heptenoate | CNPY3, CYP8B1, HPD | NR4A2 3842/4885PDE4D 247/4885NR1I2 3858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.