SCHEMBL28990298

SCHEMBL28990298

O=C1Oc2ccc(Cl)cc2C[C@@H]1F

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
AHR P35869 3/20 0.38
HRH4 Q9H3N8 1/20 0.38
HRH3 Q9Y5N1 1/20 0.38
CCNE1 P24864 1/20 0.36
CDK2 P24941 1/20 0.36
MAOB P27338 3/20 0.35
TERT O14746 1/20 0.35
GLS O94925 2/20 0.35
AADAT Q8N5Z0 1/20 0.35
NOTUM Q6P988 1/20 0.35
SRD5A1 P18405 2/20 0.35
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
MAOA P21397 2/20 0.34
AR P10275 1/20 0.33
METAP1 P53582 1/20 0.33
PNMT P11086 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28990302 1.00 AHR (0.38) AHRHRH4HRH3CCNE1CDK2
SCHEMBL30374043 0.87 AHR (0.38) AHRMAOBTERTAADATNOTUM
SCHEMBL28990299 0.87 AHR (0.38) AHRMAOBTERTAADATNOTUM
SCHEMBL28990303 0.87 AHR (0.38) AHRMAOBTERTAADATNOTUM
SCHEMBL30373799 0.81 FABP6 (0.37) HRH3MAOBNOTUM
SCHEMBL28990343 0.81 FABP6 (0.37) HRH3MAOBNOTUM
SCHEMBL28990345 0.81 FABP6 (0.37) HRH3MAOBNOTUM
SCHEMBL30374092 0.80 GAA (0.42) MAOBAADATSRD5A1
SCHEMBL28990325 0.80 SIRT1 (0.40) AHRCCNE1CDK2GLSMETAP1
SCHEMBL28990329 0.80 SIRT1 (0.40) AHRCCNE1CDK2GLSMETAP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115991695-B Method for preparing 3-fluorochromanone by metal-free catalytic hydrogenation 中国科学院化学研究所 2024-06-21 CN disclosed
CN-115991695-A Method for preparing 3-fluorochromanone by metal-free catalytic hydrogenation 中国科学院化学研究所 2023-04-21 CN disclosed