SCHEMBL28990345

SCHEMBL28990345

O=C1Oc2ccc(F)cc2CC1F

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FABP6 P51161 1/20 0.37
ACHE P22303 1/20 0.37
MAOB P27338 9/20 0.36
CYP19A1 P11511 1/20 0.34
MLNR O43193 1/20 0.32
ADRB2 P07550 1/20 0.32
ADRB1 P08588 1/20 0.32
HTR1A P08908 1/20 0.32
ADRA2A P08913 1/20 0.32
ADORA3 P0DMS8 1/20 0.32
CHRM1 P11229 1/20 0.32
DRD2 P14416 1/20 0.32
KCNE1 P15382 1/20 0.32
ADRA2B P18089 1/20 0.32
ADRA2C P18825 1/20 0.32
CNR1 P21554 1/20 0.32
SLC6A2 P23975 1/20 0.32
NPY1R P25929 1/20 0.32
HTR2A P28223 1/20 0.32
HTR2C P28335 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28990343 1.00 FABP6 (0.37) FABP6ACHEMAOBCYP19A1MLNR
SCHEMBL30373799 1.00 FABP6 (0.37) FABP6ACHEMAOBCYP19A1MLNR
SCHEMBL28990322 0.86 ACHE (0.40) FABP6ACHEMAOBCYP19A1
SCHEMBL30374028 0.86 ACHE (0.40) FABP6ACHEMAOBCYP19A1
SCHEMBL28990324 0.86 ACHE (0.40) FABP6ACHEMAOBCYP19A1
SCHEMBL28990329 0.81 SIRT1 (0.40) ADRA2ASIRT2
SCHEMBL28990298 0.81 AHR (0.38) MAOBHRH3NOTUM
SCHEMBL28990302 0.81 AHR (0.38) MAOBHRH3NOTUM
SCHEMBL28990339 0.81 GAA (0.42) ACHEMAOBSIRT2
SCHEMBL30374092 0.81 GAA (0.42) ACHEMAOBSIRT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115991695-B Method for preparing 3-fluorochromanone by metal-free catalytic hydrogenation 中国科学院化学研究所 2024-06-21 CN disclosed
CN-115991695-A Method for preparing 3-fluorochromanone by metal-free catalytic hydrogenation 中国科学院化学研究所 2023-04-21 CN disclosed