Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.47 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.47 |
| ▸ | GGT1 | P19440 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL27577799 | 0.95 | TSHR (0.47) | ALDH1A1HSD17B10KDM4EHPGDTSHR | |
| Succinic Acid SCHEMBL28992465 | 0.95 | TSHR (0.47) | ALDH1A1HSD17B10KDM4EHPGDTSHR | |
| SCHEMBL154741 | 0.91 | ALDH1A1 (0.58) | ALDH1A1ALOX15HSD17B10KDM4EHPGD | |
| Phthalic Acid SCHEMBL27618505 | 0.91 | ALDH1A1 (0.58) | ALDH1A1ALOX15HSD17B10KDM4EHPGD | |
| SCHEMBL27587077 | 0.89 | ALDH1A1 (0.56) | ALDH1A1ALOX15HSD17B10KDM4EHPGD | |
| SCHEMBL28533754 | 0.89 | ALDH1A1 (0.56) | ALDH1A1ALOX15HSD17B10KDM4EHPGD | |
| SCHEMBL27748399 | 0.89 | ALDH1A1 (0.56) | ALDH1A1ALOX15HSD17B10KDM4EHPGD | |
| Acetic Acid SCHEMBL28815277 | 0.89 | ALDH1A1 (0.56) | ALDH1A1ALOX15HSD17B10KDM4EHPGD | |
| SCHEMBL27774451 | 0.89 | ALDH1A1 (0.56) | ALDH1A1ALOX15HSD17B10KDM4EHPGD | |
| Butyric Acid SCHEMBL29276448 | 0.86 | ALDH1A1 (0.49) | ALDH1A1HSD17B10KDM4EHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115697306-A | Solid oral composition comprising a composite monolithic matrix for the chronotropic administration of active principles in the gastrointestinal tract | 莫戈恩药物有限公司 | 2023-02-03 | — | — | CN | disclosed |