Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.43 |
| ▸ | GGT1 | P19440 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.43 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL28992465 | 1.00 | TSHR (0.47) | TSHRALDH1A1NR4A2HSD17B10KDM4E | |
| Succinic Acid SCHEMBL28992466 | 0.95 | ALDH1A1 (0.49) | TSHRALDH1A1NR4A2HSD17B10KDM4E | |
| Butyric Acid SCHEMBL29276448 | 0.91 | ALDH1A1 (0.49) | TSHRALDH1A1HSD17B10KDM4ETDP1 | |
| SCHEMBL27928279 | 0.88 | ALDH1A1 (0.54) | TSHRALDH1A1HSD17B10KDM4ETDP1 | |
| Acetic Acid SCHEMBL28536661 | 0.88 | TSHR (0.48) | TSHRALDH1A1HSD17B10KDM4ETDP1 | |
| SCHEMBL2778 | 0.88 | TSHR (0.52) | TSHRALDH1A1HSD17B10KDM4ETDP1 | |
| SCHEMBL30084385 | 0.88 | TSHR (0.52) | TSHRALDH1A1HSD17B10KDM4ETDP1 | |
| Acetone SCHEMBL29281281 | 0.86 | TSHR (0.50) | TSHRALDH1A1HSD17B10KDM4ETDP1 | |
| SCHEMBL1896602 | 0.86 | TSHR (0.50) | TSHRALDH1A1HSD17B10KDM4ETDP1 | |
| SCHEMBL6383298 | 0.86 | TSHR (0.50) | TSHRALDH1A1HSD17B10KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104918608-A | Pharmaceutical compositions of CETP inhibitors | REDDYS LAB LTD DR | 2015-09-16 | — | — | CN | claimed |
| CN-1523979-A | Pharmaceutical compositions of adsorbates of amorphous drug | �Ʒ� | 2004-08-25 | — | — | CN | claimed |
| CN-1418089-A | Pharmaceutical composition of glycogen phosphorylase inhibitor | PFIZER PROD INC (US) | 2003-05-14 | — | — | CN | claimed |
| CN-109078015-A | The solid dosage of orexin receptor antagonists | 默沙东公司 | 2018-12-25 | — | — | CN | disclosed |
| CN-104918608-A | Pharmaceutical compositions of CETP inhibitors | REDDYS LAB LTD DR | 2015-09-16 | — | — | CN | disclosed |
| CN-104321059-A | solid dosage formulations of orexin receptor antagonists | MERCK SHARP & DOHME | 2015-01-28 | — | — | CN | disclosed |
| CN-102026612-A | Modification of particulate-stabilised fluid-fluid interfaces | UNILEVER PLC | 2011-04-20 | — | — | CN | disclosed |
| CN-101573110-A | Methods of lowering glucose levels | SANOFI AVENTIS DEUTSCHLAND (DE) | 2009-11-04 | — | — | CN | disclosed |
| CN-1787808-A | Method for preparing homogeneous spray-dried solid amorphous drug dispersions using pressure nozzles | PFIZER PROD INC (US) | 2006-06-14 | — | — | CN | disclosed |
| CN-1523979-A | Pharmaceutical compositions of adsorbates of amorphous drug | �Ʒ� | 2004-08-25 | — | — | CN | disclosed |
| CN-1418089-A | Pharmaceutical composition of glycogen phosphorylase inhibitor | PFIZER PROD INC (US) | 2003-05-14 | — | — | CN | disclosed |